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- agmatine ureohydrolase 精胺脲水解酶
- This paper aims to study the effect of agmatine on pc12 cell line injury. 摘要探讨了胍基丁胺对谷氨酸诱导PC12细胞DNA损伤的影响。
- Agmatine is a novel neurotransmitter and/or neuromodulator, which is the endogenic ligand of the imidazoline receptors. 摘要胍丁胺是一种新的神经递质和／或神经调质，是咪唑啉受体的内源性配体。
- To study the effect of agmatine (Agm) on L-type calcium current (ICa-L) in rat ventricular myocytes. 目的:观察胍丁胺(Agm)对大鼠心室肌细胞L-型钙通道电流(I_(Ca-L))的影响.
- Agmatine is a novel neurotransmitter and/or neuromodulator,which is the endogenic ligand of the imidazoline receptors. 胍丁胺是一种新的神经递质和/或神经调质,是咪唑啉受体的内源性配体。
- As an amine and organic cation, agmatine also has much more targets in vivo like the NMDA receptor. 它作为一种阳离子胺类物质，除了咪唑啉受体外，在生物体内还存在多个作用靶点，NMDA受体是其中最重要的作用靶点之一。
- As an amine and organic cation,agmatine also has much more targets in vivo like the NMDA receptor. 它作为一种阳离子胺类物质,除了咪唑啉受体外,在生物体内还存在多个作用靶点,NMDA受体是其中最重要的作用靶点之一。
- The effects of agmatine ( Agm) on the discharges of neurons in CA1 area of hippocampal slices were examined by using extracellular recording technique. 应用细胞外记录单位放电技术,在大鼠海马脑片上观察了胍丁胺(agmatine,Agm)对CA1区神经元放电的影响。
- In our previous work, agmatine was proved to enhance morphine analgesia, inhibit tolerance to and physical dependence on morphine. 胍丁胺是咪唑啉受体的内源性配体,我们和国外实验室先后研究发现胍丁胺增强吗啡镇痛,对抗吗啡耐受及躯体依赖。
- Previous studies showed agmatine, an endogenous I1-imidazoline receptor ligand, prevents morphine dependence, but the mechanism remains unclear. 尽管以前研究表明胍丁胺能够抑制吗啡依赖，但其作用机制尚不明确。
- The hemodynamic effects of intravenous injection of agmatine and their cellular mechanism were investigated in anesthetized rats. 在麻醉大鼠研究静注胍基丁胺(AGM)对血流动力学的影响, 并初步探讨其机制。
- The cardiac electrophysiological effects of agmatine (AGM) were examined in guinea pig papillary muscle using intracellular microelectrode technique. 应用细胞内微电极技术, 观察了胍基丁胺(agmatine, AGM)对豚鼠乳头肌细胞的电生理效应。
- The effect of agmatine (Agm) on vascular tension and the underlying receptor mechanism were investigated in the isolated aortic artery of rats. 采用离体血管环灌流方法, 观察了胍丁胺(agmatine, Agm)对大鼠胸主动脉张力的影响, 并探讨其受体机制。
- In rat CPP model, agmatine (0.75-20 mg/kg, sc) co-administered with morphine inhibited the development, expression and the priming of CPP induced by morphine. 在条件性位置偏爱(CPP)模型上;吗啡处理大鼠9d可形成明显CPP。 胍丁胺(0.;75-20mg/kg;sc)伴随吗啡给药抑制CPP的形成、表达和小剂量吗啡诱导的复发。
- Objective: This study investigates the damage of PC12 cells induced by Glutamate, and the possible neuro-protective effect of agmatine against the cell damage. 目的：研究一定浓度谷氨酸对PC12细胞的损伤作用，同时观察胍基丁胺对谷氨酸作用的影响，并初步探讨胍基丁胺的作用机制。
- Li, et al separated a molecule from bovine brain cortex that could substitute clonidine and was approved as agmatine (AGM) in 1994. Agmatine is transformed by L-arginine in function of arginine decarboxylase. 1994年Li等从牛脑中分离出一个具有可乐定替代物质特性的分子,研究证实是胍基丁胺(agmatine, AGM)。
- The results suggest that agmatine may inhibit morphine abstinence syndrome,the possible mechanisms include activation of imidazoline receptors,prevention of cAMP up-regulation and over-shooting,and inhibition of NOS activity. 胍丁胺可抑制吗啡的戒断症状,其可能的机制是通过激活咪唑啉受体抑制cAMP的上调和戒断时的超射及抑制NOS的活性。
- It turns out that agmatine can inhibit PC12 cell line DNA injury induced by glutamate through block NMDA-R and improve mitochondrial function and reduce glutamate oxidative toxicity. 这说明胍基丁胺具有抑制PC12细胞DNA损伤的作用，其机制可能与其拮抗NMDA受体，改善线粒体功能和减轻谷氨酸的氧化毒性有关。
- The method is to use glutamate with certain concentration to induce DNA injury of PC12 cell line and observe the effect of agmatine on DNA fragment and mitochondrial function simultaneously. 在用一定浓度的谷氨酸诱导PC12细胞DNA断裂的同时，观察胍基丁胺对其DNA断裂和线粒体功能的影响，发现胍基丁胺能明显减轻谷氨酸诱导PC12细胞DNA断裂并能改善线粒体功能。
- Keywords imidazoline receptors;depression;agmatine; 咪唑啉受体;抑郁症;胍丁胺;
