Li, et al separated a molecule from bovine brain cortex that could substitute clonidine and was approved as agmatine (AGM) in 1994. Agmatine is transformed by L-arginine in function of arginine decarboxylase.

• 1994年Li等从牛脑中分离出一个具有可乐定替代物质特性的分子,研究证实是胍基丁胺(agmatine, AGM)。