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- KLF6 gene suppresses hepatocellular carcinoma cell proliferation,which may be partially associated with the upregulation of p21(WAF1) expression. KLF6基因表达水平的下降可能在原发性肝癌发病机制中起到一定作用。 上调p21WAF1表达是KLF6基因抑制肝癌细胞增殖的重要途径.
- Expression of p16 INK4A was detected slightly and p21 WAF1 was not expression in SW1116 and Colo-320 cells before treatment. 正常情况下 ,SW1116和Colo 32 0细胞中均有较弱的p16 INK4A表达 ; 两种结肠癌细胞系p2 1WAF1表达缺如。
- Objective To investigate the correlations between spiral CT (SCT) findings and the expressions of p21 WAF1, p16 INK4 and PCNA in hepatocellular carcinoma (HCC). 目的 探讨肝细胞癌 (HCC)螺旋CT(SCT)表现特征与癌细胞中p2 1WAF1、p16 INK4 及PCNA表达的关系。
- Results p16 INK4A expression was weakly detected in three colon cancer cells (HT 29,SW1116 and Colo 320) and p21 WAF1 expression was not detected in SW1116 and Colo 320 cells before treatment. 结果 干预前 ,HT 2 9、SW 1116和Colo 32 0三种结肠癌细胞系中均有较弱的 p16 INK4A表达 ; SW 1116和Colo 32 0细胞的p2 1WAF1表达缺如。
- Expression of p16 INK4A and APC was detected slightly and p21 WAF1 expression was lost, as well as p53, p73, c myc, c Ki ras, survivin genes expressed in SW1116 and Colo 320 cells before treatment. 正常情况下 ,SW 1 1 1 6和Colo 32 0细胞系中均有较弱的 p1 6 INK4A和APC表达 ; 两种结肠癌细胞系 p2 1 WAF1 表达缺如 ,而 p5 3、p73和c myc、c Ki ras以及survivin均表达。
- In SW1116 and Colo 320 cells, the expression of p16 INK4A and APC genes was markedly increased after treatment of 5 aza dC, although 5 aza dC treatment did not activate the expression of p21 WAF1 gene. 以 5 aza dC干预后 ,p1 6 INK4A和APC表达增强 ,且不同的结肠癌细胞系表达增强最明显时 5 aza dC干预的时间与浓度不同。
- In SW1116 and Colo-320 cells, the expression of p16 INK4A gene was markedly increased after treatment of 5-aza-dC, although 5-aza-dC treatment did not activate the expression of p21 WAF1 gene. 5 aza dC干预后 ,p16 INK4A表达增强 ,相反p2 1WAF1仍无明显表达。
- In positive cases, the percentage of P21(superscript WAF1) positive cells showed no difference in ALL and AML ,samples, while integral positive ratio in AML was lower than that in ALL. 阳性病例P21(上标WAF1)阳性细胞百分率在ALL与AML中无差异、但积分显示阳性程度AML弱于ALL;
- Results Findings showed that the positive ratios of P21(superscript WAF1) and P27(superscript KIP1) in total samples , ALL samples and AML ,samples were lower than the control group (P<0.05). 结果32例白血病骨髓涂片标本中P21(上标WAF1)或P27(上标KIP1)在ALL、AML及总标本中表达阳性率均低于对照组(P均<0.;05)。
- ATRA and/or NaB both stimulated p21 expr ession at the mRNA levels. ATRA和 (或 )NaB均上调P2 1mRNA的水平。
- Role of Interaction of p21 and E2F Played in PGA2 mediated G1 Arrest. G1阻滞中p21-E2F间的相互作用
- Objective: To investigate the role of p21 gene in gax gene inhibiting vascular smooth muscle cells(VSMC) proliferation. 目的:研究p21基因在gax基因抑制血管平滑肌细胞(VSMC)增殖中的作用。
- Expression of N-ras Oncogene Products p21 Protein in Skin and Soft Tissue Neoplasmas. N-ras基因产物p21蛋白在皮肤、软组织肿瘤中的表达
- Meantime, Dex could inhibit MCF-7 cell cycle progression in the 0,/G, phase, the expression of p21 had little changes. Dex作用MCF-7细胞后,细胞周期也停滞在G/G; 期,但P21州 的表达无明显变化。
- There was significant correlation between the expression of c erbB 2, p21 ras and histological grade ( P <0.05). c erbB 2 ;p2 1ras蛋白表达在肺癌分化程度中呈负相关 (P <0 0 5 )。
- There were higher expression of Bax,Bcl 2,P16 and P21 in the GAC subjects with higher differentiation ( P <0.05). 高分化胃腺癌中Bcl 2、Bax、P2 1 WAF1、P16 MTS1表达较低分化者高 ;
- Objective To investigate the expressions and significance of P21 and P27 proteins in ovarian carcinoma. 摘要目的探讨P21和P27蛋白在卵巢癌组织中的表达及其意义。
- Methods Expression of p21 gene was detected by using LSAB immunohistochemistry technique in 20 cases of NB. 方法应用酶标链霉亲合素-生物素(LSAB)免疫组化技术对20例NB检测。
- The environment of nucleotide-binding pocket and Structural change of ras P21 upon GTP hydrolysis are discussed. 对ras P21核苷酸结合口袋的微环境和ras P21在CTP水解过程中的结构变化进行了讨论。
- That could be why Sedivy's mutated p21 cells died after they got in their extra rounds of mitosis. 这或许能解释塞迪维的p21突变细胞,在多分裂了几次以后,还是死去了。