In SW1116 and Colo-320 cells, the expression of p16 INK4A gene was markedly increased after treatment of 5-aza-dC, although 5-aza-dC treatment did not activate the expression of p21 WAF1 gene.

• 5 aza dC干预后 ,p16 INK4A表达增强 ,相反p2 1WAF1仍无明显表达。