In SW1116 and Colo 320 cells, the expression of p16 INK4A and APC genes was markedly increased after treatment of 5 aza dC, although 5 aza dC treatment did not activate the expression of p21 WAF1 gene.

• 以 5 aza dC干预后 ,p1 6 INK4A和APC表达增强 ,且不同的结肠癌细胞系表达增强最明显时 5 aza dC干预的时间与浓度不同。