Expression of p16 INK4A and APC was detected slightly and p21 WAF1 expression was lost, as well as p53, p73, c myc, c Ki ras, survivin genes expressed in SW1116 and Colo 320 cells before treatment.

• 正常情况下 ,SW 1 1 1 6和Colo 32 0细胞系中均有较弱的 p1 6 INK4A和APC表达 ; 两种结肠癌细胞系 p2 1 WAF1 表达缺如 ,而 p5 3、p73和c myc、c Ki ras以及survivin均表达。