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- PTC124 is an orally administered small molecule that targets a type of disease-causing genetic error known as a nonsense mutation, or premature stop codon. PTC124是一种口服式小分子化合物,它的标的是针对一些因为”无义”基因突变的疾病。
- The precore stop codon mutation was found in 7 AsCs and 10 CAH cases. AsC与CAH组中,前C终28变异分别为7例和10例;
- An "agg" codon between 1039-1041bp in PLF gene was replaced with a "taa" stop codon through primers design and PCR. 猪乳铁蛋白基因1039-1041bp处为agg密码子,在设计引物时突变为taa终止密码子。
- Three other tumors contained heteroplasmic COI mutations, one of which created a stop codon. 接着,他们对来自260个前列腺癌组织样品或血细胞的COI基因进行了测序。
- Stop codon was knocked down from porcine IFN gene when the downstream primer was designed. 此信号肽能引导目的蛋白离开细胞,分泌于培养基中,方便蛋白质提取与纯化。
- This mutation predicts the substitute of glutamic acid at codon 189 by the stop codon (Glu189X or E189X). 该突变导致第189位编码谷氨酸的密码子被终止密码代替(E189X)。
- The total number of nucleotides between a stop codon of rbcL gene and a HindIII site in cemA gene were 2 808 and 2 810 bp in Ae. 从rbcL基因的终止密码子到cemA基因内的HindIII位点;Ae.
- Using the home-made Perl programs, we extracted the concerned bases upstream and downstream of both the initiator codon and the stop codon for analysis. 通过自编的系列Perl程序,从智人RefSeq数据库中分别抽取mRNA序列起始密码子、终止密码子上、下游一定数目碱基进行分析,得出以下主要结论:
- DNA sequencing revealed that the IPNS gene of S. cattleya consists of 963 bp encoding a protein of 321 amino acids with ATG as start codon, TGA as stop codon. 经基因序列分析表明牲畜链霉菌中IPNS基因;由963bp组成;起始密码子为ATG;终止密码子为TGA;共编码321个氨基酸;所克隆的牲畜链霉菌IPNS基因编码蛋白与已知的S.
- A protein called a release factor binds directly to the stop codon, causing the addition of a water molecule instead of an amino acid to the polypeptide chain. 一种叫做释放因子的蛋白质直接结合在终止密码子上,导致一个水分子而不是氨基酸被加在肽链末端。
- The underlined nucleotides are the first upstream in-frame stop codon and the two putatie polyadenylation signals, respectiely.The asterisk indicates the stop codon. 加下划线的核苷酸分别是这个读码框中上游的第一个终止密码和两个已经认定的多核苷酸序列.;星号标记的就是终止密码
- However hybridomas derived from the MOPC-21 myeloma ancestor contains two kinds of kappa chain transcripts, namely the correct (functional) and aberrant one, which causes the VJ rearrangement out of the normal reading frame, and results in a stop codon. 目前多数骨髓瘤细胞系来源于MOPC-21细胞,而且含有两种k轻链转录子,即正常(功能性)和异常轻链转录子。
- In vitro synthesized protein assay(IVSP), which selectively detected any mutation generating stop codon, was used for rapid detection of APC gene mutation in 115 cases of non FAP colorectal tumors. 为了快速检出APC基因突变,应用选择性检测产生终止密码突变的体外蛋白合成试验(IVSP),对115例Non-FAP大肠肿瘤标本进行了研究。
- There was only one mutant , the NO. 880 base to down-side the translation stop codon (TAA).But the mutant was dispeared when conpare it with the sequence of Streptococcus mutans reported in Genebank. 本实验将反向PCR方法与核酸内切酶设计相结合诱导变形链球菌乳酸脱氢酶基因缺失突变,实验证实该方法只需设计一对反向PCR引物,进行一轮PCR反应,一次酶切连接反应,方法简便快捷。
- This method returns true if it decides that the DrawImage method should prematurely stop execution. 如果此方法决定DrawImage方法应过早停止执行,则此方法返回true。
- The baby was five weeks premature. 这个孩子是提早五周生下来的。
- He ventured a premature opinion at the meeting. 他在会上大胆发表了一个不成熟的意见。
- She was a bit too premature in giving up this job. 她放弃这份工作似嫌太草率。
- Premature babies are kept alive in incubators. 早产婴儿放在保温箱里保育。
- This disease produces premature aging of the brain. 这种疾病使大脑过早衰老。