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- bispecific antobodie 双特异性抗体
- The bispecific antibody could induce P BLs to cytotoxic test of colonic cells in vivo. 双功能抗体能够介导PBLs对CL187细胞的杀伤作用。
- The construction of a single-chain bispecific antibody COC183B2/anti-CD3 was successful. 成功构建抗人卵巢癌COC183B2 /抗CD3scBsAb ;
- AIM: To study the pharmacokinetics of conjugate of urokinase with bispecific monoclonal antibody against urokinase and fibrin (UK BI9E 11 ) in mice. 目的 :研究尿激酶 -抗尿激酶抗纤维蛋白双特异单克隆抗体复合物 (U K- BI9E1 1 )在小鼠体内的药物动力学特征。
- Objective To prepare a bispecific antibody (BsAb) against CD3 and TNP and to test its cytotoxic effect against the gastric cancer cell line,MGC803. 目的以化学方法将抗CD3及抗三硝基苯(TNP)单克隆抗体交联为双功能抗体,研究此双功能抗体与任何TNP化的抗肿瘤单抗结合,介导对肿瘤细胞的杀伤作用。
- Conclusion: The second set hybridtumortechnology to prepare the bispecific antibody had a homogeneous titer, an idealsignal-to-noise ratio and was easy to be standardized. 结论:采用二次杂交瘤技术制备的双功能抗体优于化学偶联法,抗体效价具有均匀性和理想的信噪比,抗体易于标准化。
- A single-chain bispecific antibody COC183B2/anti-CD3 is constructed and expressed successfully, which can keep approximately the antigen-binding affinity of the two parent ScFvs. 构建和表达抗人卵巢癌COC183B2 /抗CD3scBsAb成功 ,且具有与抗原OC183B2、CD3结合的免疫学活性
- In order to improve the therapeutic utility of antibodies, different modifications have been suggested.One of them concerns the generation of bispecific antibody (BsAb). 为了增强抗体的效应功能,人们尝试多种方法改造抗体分子,双特异性抗体是改善抗体治疗效果的发展方向之一,现已成为抗体工程研究领域的热点。
- Bispecific monoclonal antibodies (BsMAb) 双特异性单克隆抗体
- bispecific monoclonal antibodies 双特异性单克隆抗体
- bispecific single-chain antibody 双特异性单链抗体
- Keywords Biological therapy;mRCA;CD55;Bispecific antibody; 免疫生物学治疗;膜补体调节蛋白;CD55;双特异性抗体;
- Keywords carcinoma of bladder;bispecific antibodies;fluorescein isothiocyanate; 膀胱癌;双特异性抗体;异硫氰酸荧光素;
- Keywords Bladder carcinoma;Bispecific antibody;LAK cells;Cytotoxicity; 膀胱癌;双功能抗体;LAK细胞;细胞毒性作用;
- Preparation of bispecific chimera antibodies and establishment of Dot-red blood cell immunological assay 双特异性嵌合抗体的制备及斑点红细胞免疫技术的建立
- New Type Bispecific Single-chain Antibodies BiTEs and Its Prospect in Cancer Clinical Trials 新型双特异性单链抗体BiTEs及其在肿瘤治疗中的应用前景
- Advance in Manufacture Method of Bispecific Antibody and Application in Treat of Dairy Cow Mastitis 双特异性抗体的研制方法及其在奶牛乳腺炎治疗中的应用
- Immunological activity of bispecific single chain antibody in treating osteosarcoma 双特异性单链抗体治疗骨肉瘤的免疫活性研究
- Functional identification of the bispecific fusion protein of CEA single-chain antibody and streptavidin 癌胚抗原单链抗体-链亲和素融和蛋白的功能鉴定
- Experimental study of the cytotoxicity of CD_3 AK after introduced bispecific monocloned antibody 双特异性抗体介导的CD_3AK体外杀伤实验研究
