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- In order to improve the therapeutic utility of antibodies, different modifications have been suggested.One of them concerns the generation of bispecific antibody (BsAb). 为了增强抗体的效应功能,人们尝试多种方法改造抗体分子,双特异性抗体是改善抗体治疗效果的发展方向之一,现已成为抗体工程研究领域的热点。
- The bispecific antibody could induce P BLs to cytotoxic test of colonic cells in vivo. 双功能抗体能够介导PBLs对CL187细胞的杀伤作用。
- The construction of a single-chain bispecific antibody COC183B2/anti-CD3 was successful. 成功构建抗人卵巢癌COC183B2 /抗CD3scBsAb ;
- Objective To prepare a bispecific antibody (BsAb) against CD3 and TNP and to test its cytotoxic effect against the gastric cancer cell line,MGC803. 目的以化学方法将抗CD3及抗三硝基苯(TNP)单克隆抗体交联为双功能抗体,研究此双功能抗体与任何TNP化的抗肿瘤单抗结合,介导对肿瘤细胞的杀伤作用。
- Conclusion: The second set hybridtumortechnology to prepare the bispecific antibody had a homogeneous titer, an idealsignal-to-noise ratio and was easy to be standardized. 结论:采用二次杂交瘤技术制备的双功能抗体优于化学偶联法,抗体效价具有均匀性和理想的信噪比,抗体易于标准化。
- A single-chain bispecific antibody COC183B2/anti-CD3 is constructed and expressed successfully, which can keep approximately the antigen-binding affinity of the two parent ScFvs. 构建和表达抗人卵巢癌COC183B2 /抗CD3scBsAb成功 ,且具有与抗原OC183B2、CD3结合的免疫学活性
- Keywords carcinoma of bladder;bispecific antibodies;fluorescein isothiocyanate; 膀胱癌;双特异性抗体;异硫氰酸荧光素;
- bispecific antibodies BsAbs
- bispecific antibodies(BsAbs) 双特异性抗体
- Keywords Biological therapy;mRCA;CD55;Bispecific antibody; 免疫生物学治疗;膜补体调节蛋白;CD55;双特异性抗体;
- Keywords Bladder carcinoma;Bispecific antibody;LAK cells;Cytotoxicity; 膀胱癌;双功能抗体;LAK细胞;细胞毒性作用;
- Our bodies produce antibodies to counteract disease. 我们的身体能产生抗体以抵抗疾病。
- Advance in Manufacture Method of Bispecific Antibody and Application in Treat of Dairy Cow Mastitis 双特异性抗体的研制方法及其在奶牛乳腺炎治疗中的应用
- Construction and expression of a single-chain bispecific antibody COC183B2/anti-CD3 against human ovarian carcinoma 抗人卵巢癌COC183B2/抗CD3单链双特异抗体的构建和表达
- Keywords Single-chain antibody fragments（ScFv）Single-chain bispecific antibody（sc-BsAb）Expression; 单链抗体;单链双特异性抗体;表达;
- Effect of bispecific antibody(Bs Ab,anti-human bladder cancer/anti-VEGF) on the proliferation of vascular endothelial cells in vitro 抗人膀胱癌/抗VEGF双功能基因抗体对血管内皮细胞增殖的影响
- Preparation of antibodies to catecholamlnes. 儿茶酚胺抗体的制备。
- Antibodies are spotted onto a glass slide. 玻片上发现抗体.
- Antibodies to MBP were detected by ELISA. ELISA法检测血清中抗MBP抗体。
- The monoclonal antibodies are aimed at EPF. 本研究制备的EPF单克隆抗体为特异性抗EPF抗体。
