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- Objective To prepare aceclofenac pellet(AFP). 目的 製備醋氯芬酸微丸。
- Aceclofenac was synthesized in 82% overall yield from sodium diclofenac and t-butyl chloroacetate viaesterification and hydrolysis. 雙氯芬酸鈉與氯乙酸叔丁酯經酯化、水解反應製得非甾體抗炎葯醋氯芬酸,收率82%25。
- OBJECTIVE：To study the therapeutic effect on adjuvant-induced arthritis and inhibitory effect on delayed type hypersensitivity(DTH) of aceclofenac. 目的：研究醋氯芬酸對佐劑關節炎大鼠的治療作用及對遲髮型超敏反應的抑制作用。
- Aceclofenac also suppressed DTH with SRBC or PC in mice when it was administered after antigen challenge,but it had no marked effect when administered before antigon challege. 醋氯芬酸於抗原攻擊后給葯，顯著抑制SRBC或PC所致小鼠遲髮型超敏反應，而抗原攻擊前給葯則無明顯作用。
- Method:Aceclofenac was synthesized from chloroacetic acid and benzyl alcohol by esterification to give benzyl chloroacetate,which subjected to condensation and hydrogenolysis. 方法:以氯乙酸為原料,和苯甲醇進行酯化反應合成氯代乙酸苄基酯,再經縮合、氫解反應製得目標化合物。
- CONCLUSION:Aceclofenac exerted marked therapeutic activity against adjuvant-induced arthritis,associated with its inhibiton to inflammatory response and DTH. 結論：醋氯芬酸對大鼠佐劑關節炎具有治療作用，其作用機制可能與其抗炎作用及對遲髮型超敏反應的抑制作用有關。
- On the other hand,the inhibitory effect of aceclofenac on DTH with SRBC or PC was also examined,orally administered before and after antigen challenge,respectively. 此外，分別於抗原攻擊前後給葯，觀察醋氯芬酸對SRBC或PC所致小鼠遲髮型超敏反應的抑制作用。
- On the base of marketing theory and study method, this paper analyzed Aceclofenac product market, and presented practical and feasible marketing strategic. 本文的寫作目的就是應用市場營銷的理論與研究方法，對HX公司醋氯芬酸的市場進行分析研究，並制定出切實可行的市場營銷策略。
- In this paper, aceclofenac(ACF), a new kind of NSAIDs was selected as the model drug and acrylic pressure sensitive adhesives were used as vehicles to prepare Aceclofenac Transdermal Patches(ATPs). 本文以非甾體抗炎葯醋氯芬酸(aceclofenac，ACF)為模型藥物，研製了以丙烯酸酯類壓敏膠為基質的醋氯芬酸貼劑(Aceclofenac transdermal patches，ATPs)。
- RESULTS:Aceclofenac significantly inhibited the primary and secondary footpad swelling,diminished the thymic atrophy and enlargement of the spleen and adrealin adjuvant-induced arthritic rats. 結果:醋氯芬酸明顯抑制關節炎大鼠的原發性和繼發性足跖腫脹,並對大鼠的胸腺萎縮、脾臟和腎上腺增重具有對抗作用,其作用強度與等劑量雙氯滅痛相近。
- Sustained-released tablet of aceclofenac 醋氯芬酸緩釋片
- Keywords aceclofenac;plasma;high performance liquid chromatography; 醋氯芬酸;血漿;高效液相色譜;
- Keywords aceclofenac;permeation enhancers;oleic acid;turpentine;azone; 醋氯芬酸;經皮滲透;油酸;松節油;氮酮;
- Treatment with aceclofenac on adjuvant-induced arthritis in rats and delayed type hypersensitivity in mice 醋氯芬酸抑制大鼠佐劑關節炎及小鼠遲髮型超敏反應
- Airtal 乙醯氯芬酸[抗炎葯]
- Aceclofenac 醋氯芬酸, 乙醯氯芬酸[鎮痛抗炎葯]
