Aceclofenac was synthesized in 82% overall yield from sodium diclofenac and t-butyl chloroacetate viaesterification and hydrolysis.

• 双氯芬酸钠与氯乙酸叔丁酯经酯化、水解反应制得非甾体抗炎药醋氯芬酸,收率82%25。