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- This article summarizes the present research tatus and applied prospects in tuberculosis DNA vaccine. 本文概述了结核病DNA疫苗研究的现状及其应用前景。
- Tuberculosis DNA vaccines 结核病疫苗
- Objective: To construct an eukaryotic co-expression recombinant containing mouse interleukin 21(IL-21) and tuberculosis antigen 85A(Ag85A), it provides the new strategy for further development of new type anti-tuberculosis DNA vaccines. 目的:利用真核表达质粒pRSC,构建结核杆菌抗原85A(Ag85A)与小鼠白细胞介素21(mIL21)共表达重组体pRSC-mIL21-Ag85A,为研究新型结核杆菌DNA疫苗提供新的策略。
- Conclusion Cellular immunity in mice could be enhanced induced by DNA vaccines based on HPV16 E6/E7. It could be much stronger induced by DNA recombinants of HSP70 of mycobacterium tuberculosis and HPV16 E6/E7. However, humoral immunity remained. 与结核杆菌HSP70重组后,IL-10及抗体水平没有明显变化。 结论以HPV16 E6/E7为基础的DNA免疫能增强小鼠的细胞免疫反应。
- Polymerase chain reaction(PCR) assay was used to detect tuberculosis dNA(TB-DNA)in two kinds of malignant tumors. 方法采用多聚酶链反应(PCR)技术检测两种恶性肿瘤组织中结核杆菌DNA(TB-DNA)。
- Detection of tuberculosis DNA in Some malignant Tumors Abstract To study the relation of mycobacterium tuberculosis infection with malignant tumors. 目的探讨结核杆菌感染与恶性肿瘤的关系。
- This review summarized the current situation of study on routes of DNA vaccines immunization. 该文对DNA疫苗免疫各种途径的研究现状作一综述。
- Results: Immune effects of DNA vaccines were enhanced following electric pulses and bupivacaine delivery. 检测免疫小鼠的抗体和细胞水平,并分析抗体亚类。
- Objective To construct a multivalent DNA vaccine. 目的构建日本血吸虫多价DNA疫苗。
- A variety of approaches have been taken to augment and modulate the immunogenicity and efficacy of plasmid DNA vaccines. 核酸疫苗虽然在小动物实验中取得成功,但对大动物、灵长类动物和人类的免疫原性却很低。
- Methods:We constructed Mycobacterium tuberculosis MPT64 antigen DNA vaccine(pM)and ubiquitin-MPT64 fusion gene DNA vaccine(pUM). 目的:用遍在蛋白质调节结核杆菌单一抗原DNA疫苗,以期获得更强的免疫保护。
- The combined PCX/S antigen gene could induce specific immune response and it might be able to serve as a bivalent DNA vaccines candidate specific for HCV and HBV. 复合型PCX/S抗原基因可诱发特异性免疫应答,为HCV/HBV双价疫苗的研究提供一定实验基础。
- PurposerConA was combined with mycobacterium tuberculosis HSP65 DNA vaccine to enhance the function of APCs and cellular immunity induced by the DNA vaccine. 目的:将刀豆蛋白A与结核杆菌HSP65 DNA疫苗联合应用于Balb/c小鼠,期望通过提高APCs的抗原递呈能力达到增强结核杆菌HSP65 DNA疫苗所诱导的细胞免疫应答的目的。
- While small animal studies have been extremely promising, the immunogenicity of DNA vaccines in larger animals, non-human primates and humans has been disappointing. 从抗原基因的选择、质粒载体的优化、接种方法的优化和免疫佐剂的选用等方面综述核酸疫苗的优化方案。
- Objective To construct a multivalent DNA vaccine encoding Ag85A,ESAT-6 and CFP-10 antigens from Mycobacterium tuberculosis,and to preliminarily study its immunogenicity. 目的构建包含结核杆菌3种抗原蛋白Ag85A、ESAT-6和CFP-10真核表达质粒的多价DNA疫苗,并对其在小鼠体内的免疫原性进行初步分析。
- Genetic vaccines and DNA vaccines are being exploited.The targets are Toxoplasma gondii, pneumocystis carinii, Cryptosporidium parvum, and Angiostrongylus cantonensis. 主要的研究对象为弓形虫、卡氏肺孢子虫、隐孢子虫、广州管圆线虫等。
- Hepatitis B vaccines progressed from blood vaccines to recombinant vaccines,then to peptide vaccines and DNA vaccines,to their functions extended from prophylactic to therapeutic. 从第一代血源性疫苗到重组乙肝疫苗,再到合成肽疫苗和DNA疫苗,乙肝疫苗的研制技术不断进步,其应用范围也已从预防扩展到治疗。
- Hepatitis B vaccines progressed from blood vaccines to recombinant vaccines, then to peptide vaccines and DNA vaccines, to their functions extended from prophylactic to therapeutic. 从第一代血源性疫苗到重组乙肝疫苗,再到合成肽疫苗和DNA疫苗,乙肝疫苗的研制技术不断进步,其应用范围也已从预防扩展到治疗。
- A combined DNA vaccine encoding Ag85B, MPT64 and MPT83 of Mycobacterium tuberculosis was formulated into DDA to immunize mice and to evaluate the immunogenicity and protective efficacy of the vaccine in the immunized mice. 将编码结核杆菌的三种抗原Ag85B,MPT64,MPT83的基因片段分别插入到真核表达载体中,混合后作为组合疫苗免疫小鼠,DDA作为佐剂提高了三价疫苗的免疫原性和免疫保护效果。
- Combined DNA vaccine encoding Ag85B, MPT64 and MPT83 of Mycobacterium tuberculosis were formulated into DDA and MPL to immunize mice and then the immunogenicity and protective efficacy of each group were evaluated. 编码结核杆菌3种抗原Ag85B;MPT64;MPT83的基因片段插入真核表达载体作为组合疫苗免疫小鼠;DDA和MPL作为佐剂分别提高了此三价苗的免疫原性和免疫保护效果;且相比之下DDA优于MPL.