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- Cyclin Kinase Inhibitor P21 细胞周期蛋白依赖性激酶抑制剂P21
- Objective: To investigate the relationship between the cyclin kinase inhibitor P27 and the effect of low protein diet on the renal hypertrophy of diabetic glomerulus. 目的:探讨低蛋白饮食对糖尿病肾病大鼠肾脏肥大的影响及其与肾小球周期素激酶抑制剂P27的关系。
- Cell treated with 10-7mol/L 1,25-(OH)2D3 changed a lot , which displayed the morphological characters of benign cell, meanwhile cell cycle was arrested at G0/G1, cyclin-dependent kinase inhibitor P21 and DPC-4/Smad4 expressions was markedly up-regulated . 10-7mol/L 1,25-(OH)2D3则对Bxpc-3细胞作用明显,表现为良性细胞的形态学特点,同时细胞周期时相分布上出现G0/G1期阻滞,细胞周期调控蛋白P21及DPC-4/Smad4蛋白的表达上调。
- Keywords EGCG;Mesangial cell;Diabetic nephropathy;Cyclin kinase inhibitor p27; 周期素激酶抑制剂;系膜细胞;糖尿病肾病;
- Keywords cell cycle regulatory protein;cyclin kinase inhibitor;glomerulonephritis;mesangial proliferative; 细胞周期蛋白类;周期素激酶抑制剂;肾小球肾炎;系膜增生性;
- Objective To investigate the significance of P21 WAF1/CIP1 (a cyclin-dependent kinase inhibitor)expression in bladder transitional cell carcinomas (TCC). 目的研究P21WAF1/CIP1基因的蛋白产物在膀胱移行细胞癌中的表达及意义。
- In the recent years, cyclin, cyc-lin dependent kinase and cyclin dependent kinase inhibitor have important effect in cell cycle modulation. 近年来发现细胞周期素(Cyclin)、细胞周期蛋白依赖激酶(Cyclin dependent kinase,CDK)和细胞周期蛋白依赖性激酶抑制因子(Cyclin dependent kinase inhibitor,CKI)在真核生物细胞周期调控有重要作用。
- P21WAF1 is a kind of cyclin dependent kinase inhibitor, it can be bind to several kinds of cyclin/CDK compounds and arrest the cell cycle. P21~(WAF1)是一种CKI,它可与多种cyclin/CDK复合物结合,引起细胞周期阻滞。
- P 27Klpl is a kind of cyclin dependnt kinase inhibitor (CKI) and it can regulate cell cycle through restraining cyclin and cyclin dependnt kinase (CDK). _p27蛋白是一种细胞周期蛋白依赖性激酶抑制剂(cyclin dependnt助兴大尝医笋朦硕生~研羌生.;早业讼戈
- The factors that regulate the cell cycle include Cyclin, Cyclin-dependent kinase(CDK), Cyclin-dependent kinase inhibitor(CKI). CyclinDl is the major control switches in the G1 phase. 参与细胞周期调控的蛋白主要有:细胞周期蛋白(Cyclin)、细胞周期蛋白依赖性激酶(Cyclin-dependent kinase,CDK)、细胞周期蛋白依赖性激酶抑制因子(Cyclin-dependent kinase inhibitor,CKI)。
- Is PDGF tyrosine kinase inhibitor effective in pancreatic cancer? PDGF受体酪氨酸激酶抑制剂在胰腺癌中是否有作用?
- P27Kipl is a multifunctional cyclin depedent kinase inhibitor (CKI) that was found recently, and to be regarded as a negative regulative restraining gene of cyclin depedent kinase( CDK) for cell cycle. P27Kipl是近年发现的一个多功能细胞周期蛋白依赖激酶抑制剂(CKI),作为CDK的抑制因子对细胞周期实行负调控。
- There are many factors that regulate the proliferation and differentiation of cells. The major factors include cyclin, cyclin dependent kinase (cdk) and cyclin dependent kinase inhibitor (CDKI). 调节细胞增殖和分化的因素有许多种,其中主要有细胞周期蛋白(cyclin)、细胞周期蛋白依赖性激酶(cyclin dependent kinase,cdk)和细胞周期蛋白依赖性激酶抑制因子(cyclin dependent kinase inhibitor,CDKI)。
- Sunitinb is a novel multitargeted receptor tyrosine kinase inhibitor. 苏尼替尼是一种新型的多靶点酪氨酸激酶抑制剂。
- cyclin dependent kinase inhibitor CK1
- The progress in tyrosine kinase inhibitor has been reviewed, including the chemical structures and the pharmacophore models. 本文综述了近年来酪氨酸激酶抑制剂的研究进展,包括抑制剂的结构和与激酶作用的药效团模型。
- And PI3 kinase inhibitor LY294002 blocked the differentiation of ADAS cells into endothelial cells in vitro. 利用信号通路特异性抑制剂抑制实验,提示PI3K在ADAS细胞向内皮细胞分化中
- Gefitinib, the first EGFR tyrosine kinase inhibitor put into clinical trial, was put into market in Japan in 2002. 吉非替尼是EGFR酪氨酸激酶抑制剂中最早进入临床试验的口服药物,2002年首次于日本上市。
- EGFR tyrosine kinase inhibitor is an investigative hot spot in targeted therapy of non-small cell lung cancer (NSCLC). 摘要EGFR靶向抑制剂,是目前NSCLC靶向治疗的研究热点之一。
- The activity of cyclin - Cdk complexes is affected by cyclin - dependent kinase inhibitors including P27kip1. P27kIp1 protein binds to cyclin D - Cdk4, cyclin E - Cdk2 and cyclinA - Cdk2 complex inhibiting their activities during the cell cycle. 目前发现的CDKI按结构和功能的不同可分成两大类:一类为Cip/Kip(CDK-interacting protein/kinase inhibition protein),包括p21~(Cip1)、p27~(kip1)、p57~(kip2)等。