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- Objective To prepare aceclofenac pellet(AFP). 目的 制备醋氯芬酸微丸。
- Aceclofenac was synthesized in 82% overall yield from sodium diclofenac and t-butyl chloroacetate viaesterification and hydrolysis. 双氯芬酸钠与氯乙酸叔丁酯经酯化、水解反应制得非甾体抗炎药醋氯芬酸,收率82%25。
- OBJECTIVE：To study the therapeutic effect on adjuvant-induced arthritis and inhibitory effect on delayed type hypersensitivity(DTH) of aceclofenac. 目的：研究醋氯芬酸对佐剂关节炎大鼠的治疗作用及对迟发型超敏反应的抑制作用。
- Aceclofenac also suppressed DTH with SRBC or PC in mice when it was administered after antigen challenge,but it had no marked effect when administered before antigon challege. 醋氯芬酸于抗原攻击后给药，显著抑制SRBC或PC所致小鼠迟发型超敏反应，而抗原攻击前给药则无明显作用。
- Method:Aceclofenac was synthesized from chloroacetic acid and benzyl alcohol by esterification to give benzyl chloroacetate,which subjected to condensation and hydrogenolysis. 方法:以氯乙酸为原料,和苯甲醇进行酯化反应合成氯代乙酸苄基酯,再经缩合、氢解反应制得目标化合物。
- CONCLUSION:Aceclofenac exerted marked therapeutic activity against adjuvant-induced arthritis,associated with its inhibiton to inflammatory response and DTH. 结论：醋氯芬酸对大鼠佐剂关节炎具有治疗作用，其作用机制可能与其抗炎作用及对迟发型超敏反应的抑制作用有关。
- On the other hand,the inhibitory effect of aceclofenac on DTH with SRBC or PC was also examined,orally administered before and after antigen challenge,respectively. 此外，分别于抗原攻击前后给药，观察醋氯芬酸对SRBC或PC所致小鼠迟发型超敏反应的抑制作用。
- On the base of marketing theory and study method, this paper analyzed Aceclofenac product market, and presented practical and feasible marketing strategic. 本文的写作目的就是应用市场营销的理论与研究方法，对HX公司醋氯芬酸的市场进行分析研究，并制定出切实可行的市场营销策略。
- In this paper, aceclofenac(ACF), a new kind of NSAIDs was selected as the model drug and acrylic pressure sensitive adhesives were used as vehicles to prepare Aceclofenac Transdermal Patches(ATPs). 本文以非甾体抗炎药醋氯芬酸(aceclofenac，ACF)为模型药物，研制了以丙烯酸酯类压敏胶为基质的醋氯芬酸贴剂(Aceclofenac transdermal patches，ATPs)。
- RESULTS:Aceclofenac significantly inhibited the primary and secondary footpad swelling,diminished the thymic atrophy and enlargement of the spleen and adrealin adjuvant-induced arthritic rats. 结果:醋氯芬酸明显抑制关节炎大鼠的原发性和继发性足跖肿胀,并对大鼠的胸腺萎缩、脾脏和肾上腺增重具有对抗作用,其作用强度与等剂量双氯灭痛相近。
- Sustained-released tablet of aceclofenac 醋氯芬酸缓释片
- Keywords aceclofenac;plasma;high performance liquid chromatography; 醋氯芬酸;血浆;高效液相色谱;
- Keywords aceclofenac;permeation enhancers;oleic acid;turpentine;azone; 醋氯芬酸;经皮渗透;油酸;松节油;氮酮;
- Treatment with aceclofenac on adjuvant-induced arthritis in rats and delayed type hypersensitivity in mice 醋氯芬酸抑制大鼠佐剂关节炎及小鼠迟发型超敏反应
- Airtal 乙酰氯芬酸[抗炎药]
- Aceclofenac 醋氯芬酸, 乙酰氯芬酸[镇痛抗炎药]
