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- Objective:To understand how chalcone inhibits the growth of human stomach cancer BGC823 ,arrests the cell cycle progress and induces cell apoptosis in order to explore a new clue to finding a cure for stomach cancer. 目的:研究查尔酮对人胃癌BGC823细胞生长抑制、细胞周期阻滞及诱导细胞凋亡的作用,为寻找预防肿瘤药物提供一定的线索。
- Meantime, Dex could inhibit MCF-7 cell cycle progression in the 0,/G, phase, the expression of p21 had little changes. Dex作用MCF－7细胞后，细胞周期也停滞在G/G； 期，但P21州 的表达无明显变化。
- Objective:In the present study the effects of melatonin (MLT) on apoptosis and cell cycle progression in mouse thymocytes in vitro was investigated. 目的 :研究褪黑素对体外培养的小鼠胸腺细胞凋亡及细胞周期进程的影响。
- This study identifies the major deubiquitinase for histone H2A and demonstrates that H2A deubiquitination is critically involved in cell cycle progression and gene expression. 研究鉴定了组蛋白H2A主要去泛素化酶并证明H2A去泛素化在参与细胞周期进程和基因表达中起着重要作用。
- Recent studies have found that p16 and p21, the specific suppressors of cyclin/CDK4/6, can regulate the phosphorylation of pRb and control the cell cycle progression through p16 - cyclm/CDK - Rb and p53 - p21 - cyclin/CDK - Rb pathway. 近年来的研究发现，许多基因通过信号传导途径调节pRb发生细胞周期依赖性磷酸化。 其中被广泛研究的是p16-cyclin/CDK-Rb途径和p53-p21-cyclin/CDK-Rb途径。
- However, cell cycle is negatively regulated by cyclin-dependent kinase inhibitor (CDKI) such as p27. p27 can bind to and inhibit the activity of cyclin-dependent kinases(CDK) thereby prevent cell cycle progression of late GI to S-phase transition. 已知细胞增殖周期受细胞周期素依赖性蛋白激酶抑制剂(cyclin-dependent kinase inhibitor，CDKI)如p27的负向调控。 p27结合并抑制细胞周期素依赖性蛋白激酶(cyclin-dependent kinase，CDK)活性，从而阻滞细胞增殖周期中DNA合成前期（G卜向DNA合成期旧）的转变。
- CDK2, one of the important members in CDK family, directly regulates the critical steps in cell cycle progression including transition of G1/S checkpoint, DNA replication and centrosome d. CDK2是CDK家族中的重要成员，它直接参与细胞周期G_1／S限制点、S期DNA复制和中心体复制的调节，它的活性和功能调节是细胞周期运转的的关键环节之一，与细胞癌变有着十分密切的关系。
- Song K, Chen YG, Goke R, et al. Tumor necrosis factor-related apopto-sis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression[J]. Clin Invest,2000,191:1095. 李宁丽;路丽明;张冬青;等.;人可溶性TRAIL分子表达与生物学活性研究[J]
- The pedal of a cycle is attached to a crank. 自行车的踏板与曲柄相连。
- His boss was dissatisfied with his tardy progress. 老板对他缓慢的进度不满意。
- We have made pleasing progress in our talks. 我们的会谈已经取得了令人满意的进展。
- Study well and make progress every day. 好好学习，天天向上。
- He made rapid progress in his studies. 他学习上进步很快。
- We can only make progress by degrees. 我们只能逐渐地进步。
- Physics has made enormous progress in this century. 本世纪物理学的发展突飞猛进。
- It's easier to cycle with the wind behind you. 顺风骑车省力。
- All these difficulties cramped his progress. 所有这些困难阻碍了他的进步。
- A unit of frequency equal to one cycle per second. 赫兹频率的单位，等于每秒一周
- I updated the committee on our progress. 我向委员会报告了我们的进展情况。
- The seasons of the year make a cycle. 一年四季构成一个循环。
