CDK2, one of the important members in CDK family, directly regulates the critical steps in cell cycle progression including transition of G1/S checkpoint, DNA replication and centrosome d.

• CDK2是CDK家族中的重要成员，它直接参与细胞周期G_1／S限制点、S期DNA复制和中心体复制的调节，它的活性和功能调节是细胞周期运转的的关键环节之一，与细胞癌变有着十分密切的关系。