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- Objective To clarify the role of a cell cycle regulator, cyclin D1 and CDK6 in patients with gastric carcinoma. 目的检测细胞周期蛋白D1(cyclin D1)和细胞周期蛋白质依赖激酶6(CDK6)在胃癌组织中的表达情况,分析其表达与胃癌的临床病理因素和预后之间的关系。
- Genes involved in transcription, RNA processing, and cell cycle regulation were particularly affected. 这些受影响的基因主要基因涉及转录、RNA加工细胞周期调控等过程。
- The isoform CDK11p58 is specifically translated in G2/M phase and has much relation with cell cycle regulation. CDK11p58特异地在G2/M 期表达，和细胞周期的调节有着密切的联系。
- Many researches show that Skp2 can interact with many cell cycle regulating factors including p27, and lead to their ubiquitination and degeneration. Skp2是F-box蛋白家族的一员。研究发现，Skp2可与包括p27在内的多种细胞周期调控因子相互作用，导致它们的泛素化降解。
- The transcription factor,E2F,playing a critical role in cell cycle regulation,is involved in the pathophysiological process of restenosis. 2F是调控细胞周期进程一个关键的转录因子,而且在血管再狭窄的病理过程中也起着非常重要的作用。
- Data from this study indicate that the inhibition of p15INK4B and p21WAF1/cip1 may be one of the mechanisms by which HDAC3 participates in cell cycle regulation and oncogenesis. 干涉质粒能诱导p15INK4B基因表达活性的升高，而对p21WAF1/cip1的表达没有什么影响。本研究表明去乙酰化酶3可能是通过抑制p15INK4B和p21WAF1/cip1这种方式来参与周期调控和癌症发生的。
- Research indicated that PI3K and MAPK signal pathways were associated with biological behaviors such as cell migration, inflammation, cell proliferation and cell cycle regulation. 已有的研究表明PI3K和MAPK信号传导通路参与了细胞迁移、炎症反应、细胞增殖和细胞周期调控等一系列过程,在肾组织纤维化的发生发展中发挥重要作用。
- Objective To analyze the correlation of cell cycle regulation factors Cyclin D1, CDK. 4, P1 6 protein and p16 gene expression with clinicopathologic features and the prognosis in colorectal carcinoma. 目的 探讨细胞周期调控因子Cyclin D1、CDK4、P16蛋白及p16基因表达与大肠癌的临床病理特征及预后的关系。
- In fact, as a specific molecular chaperone, HSP90 proteins are possibly involved in many important physiological processes such as signal transduction, cell cycle regulation and hormone response. 事实证明，作为一种特异的分子伴侣，HSP90除在细胞正常生长和应急保护中具有重要生理功能外，还与信号传导、细胞周期调控、激素应答等细胞内重要生理过程有关。
- In order to build up a gastric carcinoma cell expressing human cyclin G2 gene stably, a useful tool for the research on the function of cyclin G2 in gastric carcinoma cell cycle regulation was made. 应用脂质体基因转染技术建立稳定表达cyclin G2基因的胃癌克隆细胞，为深入研究cyclin G2在胃癌细胞周期调控的作用和机制提供理想的生物学模型。
- In summary, we here report that cyclin D3/CDK11p58 signaling is involved in the transcriptional regulation in eukaryotic cells as well as the cell cycle regulation. 综上所述，我们发现cyclin D3/CDK11p58信号途径除能调控细胞周期外，也参与了真核细胞的转录调控。
- The Expression of Cell Cycle Regulators in Primary and Relapsing Nasopharyngeal Carcinoma 细胞周期调节因子在原发和复发鼻咽癌的表达
- Keywords Breast;Papillomatosis;Cell cycle regulators;Protein expression;Ductal carcinoma in situ; 乳腺;乳头状瘤病;细胞周期调控因子;蛋白表达;导管内癌;
- Micro Mechanisms of Cell Cycle Regulation and Checkpoint Control 细胞周期调控的分子机制与关卡调控
- cell cycle; cell cycle regulatory proteins;glomerular disease;P27 细胞周期；细胞周期调控蛋白；肾小球疾病；P27
- Flow Cytometry applyed to analysis cell cycle. 采用流式细胞仪分析细胞周期。
- And cell cycle was arrested of G0/ G1 phase. 并且将细胞周期阻滞于G0/G1期。
- cell cycle regulators 细胞周期调控子
- E1A gene can effectively enhance the radiosensitivity of human cervical carcinoma cells and its mechanisms of action may relate to the suppression of Her-2 expression and a redistribution of cell cycles regulated by E1A gene. E1A基因能够明显提高人宫颈癌细胞对放射线的敏感性,其作用机制可能与E1A基因抑制了该细胞Her-2基因的表达,使细胞周期再分布有关。
- Expression of cell cycle regulators in human bronchial epithelial cells malignantly transformed by cyclophosphamide and thiotepa 环磷酰胺及塞替派诱导的人支气管上皮恶性转化细胞的细胞周期相关蛋白表达
