Objective To analyze the correlation of cell cycle regulation factors Cyclin D1, CDK. 4, P1 6 protein and p16 gene expression with clinicopathologic features and the prognosis in colorectal carcinoma.

• 目的 探讨细胞周期调控因子Cyclin D1、CDK4、P16蛋白及p16基因表达与大肠癌的临床病理特征及预后的关系。