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- Telomerase hTERT, rather than hTR, could be up-regulated in lesions from psoriasis, BCC, SCC and SK, and should be represented as a new molecular marker as Ki-67 for cell proliferation. hTERTmRNA与细胞增殖活性有关,在银屑病、基底细胞癌、鳞癌、脂溢性角化中的表达明显升高,可作为细胞增殖活性的分子生物学标志。
- Detection of telomerase hTERT gene expression in primary lung cancer and exfoliated cell in malignant pleural effusion 原发性肺癌和癌性胸液脱落细胞端粒酶hTERT基因表达的检测
- Telomerase hTERT 端粒酶hTERT
- Compared to HTR, HTERT expression was better associated with telomerase activity with a concordance of 88.9%. 与HTR相比，HTERT同端粒酶具有更高的一致性，其一致率为88.;9%25。
- These findings suggest that hTERT gene expression and telomerase activity may be valuable tumor maker for EOC early diagnosis but its prognostic value needs to be further studied. hTERT表达及端粒酶活性可望作为有价值的肿瘤标志物而用于卵巢癌的早期诊断 ,但其预后价值尚有待于进一步研究。
- Overexpression of MKRN1 in telomerase-positive cells promotes the degradation of hTERT and decreases telomerase activity and subsequently telomere length. 在实验中，MKRN1蛋白能将肿瘤细胞中的端粒酶清除掉。令人惊奇的是MKRN1基因非常古老。
- No telomerase activity in human penile tissue. 人阴茎组织中无端粒酶活性。
- The positive rate of telomerase and hTERT mRNA were 43% and 53% respectively in meningiomas? and the positive rate and level of expression were increased in ascending order with the degree of malignancy of tumors as well. 脑膜瘤端粒酶阳性率为43%25,hTERT阳性率53%25,两者阳性率和活性水平都随肿瘤恶性度增加而升高。
- Objective To investigate the effect of cis-Diamminedichloroplatinum(DDP) with different dose and time on human telomerase reverse transcriptase(hTERT) mRNA expression in human hepatocellular line BEL-7404and BEL-7404/ADM. 目的观察不同浓度及作用时间顺铂对BEL-7404、BEL-7404/ADM肝癌细胞hTERT-mRNA表达及影响。
- Objective To study selective killing effect of herpes simplex virus-thymidine kinase/ganciclovir(Hsv-tk/GCV) driven by human telomerase catalytic subunit (hTERT) promoter on lung cancer cell line A549 in vitro. 目的研究人端粒酶催化亚单位(human telomerase catalytic subunit,hTERT)基因启动子调控单纯疱疹胸苷激酶/更昔洛韦(herpes simplex virus-thymidine kinase/ganciclovir,Hsv-tk/GCV)治疗系统对人肺癌细胞株A549的选择体外杀伤作用。
- The formation of neurofibromas in the patients with non-NF1 was only associated with the increased activity of telomerase resulting from the increased expression of hTERT protein, and was not associated with the absent expression of NF1 protein. 而非NF1患者神经纤维瘤的形成与hTERT蛋白表达增加，端粒酶活性增高有关，与NF1蛋白表达缺失无关。
- Methods hTERT mRNA expression and telomerase activity were analyzed in 43 samples of EOC,11 benign ovarian tumors and normal ovarian tissues,as well as 4 borderline ovarian tissues with the use of RT-PCR and telomeric repeat amplification protocol(TRAP). 方法 应用RT PCR及端粒重复扩增方法对 43例上皮性卵巢癌、11例良性卵巢肿瘤和卵巢正常组织以及 4例交界性卵巢肿瘤共 69份标本进行hTERTmRNA及端粒酶活性检测。
- The mechanism of telomerase activation is still not clear till now. 端粒酶的激活及其调控机制至今仍不清楚。
- Telomerase system is the genetic name of telomerase and telomere. 端粒酶系统是端粒和端粒酶的总称。
- human telomeras reverse transcriptase (hTERT) 人端粒酶逆转录酶（hTERT）
- Methods:A plasmid including U6 promoter and siRNA of hTERT was designed and constructed. The plasmid was transfected into ALVA-41 cell line. The telomerase activity was tested by telomerase repeat amplification protocol ELISA(TRAP-ELISA). 方法:设计和构建由U6启动子驱动产生hTERT的siRNA表达质粒,转染至ALVA-41前列腺肿瘤细胞,以TRAP-ELISA方法观察细胞端粒酶活性,W estern-b lot检测端粒酶蛋白的表达,细胞记数法检测对细胞生长的影响。
- Results In 68 lung cancer tissues, telomerase activity, HTR and HTERT were expressed in 79%, 98.5%and 91.2%respectively, whereas all adjacent non-neoplastic lung tissues were telomerase negative. 结果68例肺癌组织中端粒酶阳性率为79%25，HTR阳性率为98.;5%25，HTERT阳性率为91
- Objective To investigate telomerase activity in patients with psoriasis. 目的探讨银屑病的端粒酶活性表达情况。
- To her surprise, she found no correlation between telomerase and longeity. 她惊奇地发现，端粒酶与寿命并不存在相关性。
- Results:Telomerase is a reverse transcriptase comprised of many subunits. 结果端粒酶是一多亚基复合物,具有逆转录酶活性。
