Overexpression of MKRN1 in telomerase-positive cells promotes the degradation of hTERT and decreases telomerase activity and subsequently telomere length.

• 在实验中，MKRN1蛋白能将肿瘤细胞中的端粒酶清除掉。令人惊奇的是MKRN1基因非常古老。