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- Meantime, Dex could inhibit MCF-7 cell cycle progression in the 0,/G, phase, the expression of p21 had little changes. Dex作用MCF－7细胞后，细胞周期也停滞在G/G； 期，但P21州 的表达无明显变化。
- Objective:In the present study the effects of melatonin (MLT) on apoptosis and cell cycle progression in mouse thymocytes in vitro was investigated. 目的 :研究褪黑素对体外培养的小鼠胸腺细胞凋亡及细胞周期进程的影响。
- This study identifies the major deubiquitinase for histone H2A and demonstrates that H2A deubiquitination is critically involved in cell cycle progression and gene expression. 研究鉴定了组蛋白H2A主要去泛素化酶并证明H2A去泛素化在参与细胞周期进程和基因表达中起着重要作用。
- Recent studies have found that p16 and p21, the specific suppressors of cyclin/CDK4/6, can regulate the phosphorylation of pRb and control the cell cycle progression through p16 - cyclm/CDK - Rb and p53 - p21 - cyclin/CDK - Rb pathway. 近年来的研究发现，许多基因通过信号传导途径调节pRb发生细胞周期依赖性磷酸化。 其中被广泛研究的是p16-cyclin/CDK-Rb途径和p53-p21-cyclin/CDK-Rb途径。
- However, cell cycle is negatively regulated by cyclin-dependent kinase inhibitor (CDKI) such as p27. p27 can bind to and inhibit the activity of cyclin-dependent kinases(CDK) thereby prevent cell cycle progression of late GI to S-phase transition. 已知细胞增殖周期受细胞周期素依赖性蛋白激酶抑制剂(cyclin-dependent kinase inhibitor，CDKI)如p27的负向调控。 p27结合并抑制细胞周期素依赖性蛋白激酶(cyclin-dependent kinase，CDK)活性，从而阻滞细胞增殖周期中DNA合成前期（G卜向DNA合成期旧）的转变。
- CDK2, one of the important members in CDK family, directly regulates the critical steps in cell cycle progression including transition of G1/S checkpoint, DNA replication and centrosome d. CDK2是CDK家族中的重要成员，它直接参与细胞周期G_1／S限制点、S期DNA复制和中心体复制的调节，它的活性和功能调节是细胞周期运转的的关键环节之一，与细胞癌变有着十分密切的关系。
- Song K, Chen YG, Goke R, et al. Tumor necrosis factor-related apopto-sis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression[J]. Clin Invest,2000,191:1095. 李宁丽;路丽明;张冬青;等.;人可溶性TRAIL分子表达与生物学活性研究[J]
- Objective:To understand how chalcone inhibits the growth of human stomach cancer BGC823 ,arrests the cell cycle progress and induces cell apoptosis in order to explore a new clue to finding a cure for stomach cancer. 目的:研究查尔酮对人胃癌BGC823细胞生长抑制、细胞周期阻滞及诱导细胞凋亡的作用,为寻找预防肿瘤药物提供一定的线索。
- EFFECTS OF WHOLE BODY IRRADIATION WITH X-RAYS ON CELL CYCLE PROGRESSION OF SPLENOCYTES IN MICE 不同剂量X射线全身照射对小鼠脾细胞周期进程的影响
- Dose Rate-Effect of Adaptive Response of Thymocyte Apoptosis and Cell Cycle Progression Induced by Low Dose X-ray Radiation in Mice 低剂量X线辐射诱导胸腺细胞凋亡及细胞周期进程适应性反应的剂量率效应
- Time-effect of adaptive response of thymocyte apoptosis and cell cycle progression induced by low dose ionizing radiation in mice 低剂量电离辐射诱导小鼠胸腺细胞凋亡及细胞周期进程适应性反应的时间效应
- p27Kip1 is a cdk inhibitor that regulates cell cycle progression from the Gl phase to the S phase by binding to the cyclin E/ cdk2 complex, there by inhibiting this kinase. p27~(Kip1)是一个cdk抑制物，通过结合在CyclinE/cdk2复合体上，调控细胞周期中G1期到S期进展，从而抑制此激酶。
- Flow Cytometry applyed to analysis cell cycle. 采用流式细胞仪分析细胞周期。
- And cell cycle was arrested of G0/ G1 phase. 并且将细胞周期阻滞于G0/G1期。
- Study on mechanism of Hep-2 cell apoptosis induced by high temperature and its effect on cell cycle progress 高温诱导Hep-2细胞凋亡及其对细胞周期进程的影响
- Cell cycle progression 细胞劂朗
- Regulation of cell cycle progression and expression of tumor suppressor genes in human colonic cancer cells by epigenetics 表型遗传修饰对人结肠癌细胞周期和抑癌基因表达的调控
- Inhibition of cell proliferation and arrest of cell cycle progression by blocking Cl- channels in nasopharyngeal carcinoma cells 抑制氯通道阻抑鼻咽癌细胞周期和细胞增殖
- PARATHYROID HORMONE AND INSULIN-LIKE GROWTH FACTOR-1 ACCELERATE THE CELL CYCLE PROGRESSION IN OSTEOBLAST-LIKE ROS17/2. 8 CELLS 甲状旁腺素、胰岛素样生长因子-1可加速成骨样细胞ROS17/2.;8增值周期的进程
- B, Stem( S)/ progenitor( P) cell inersion through the cell cycle. 干细胞/祖细胞(/)化模型.;大量目前的研究对传统的模型提出了质疑。
