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- Wild type p53 genes promote G 1 phase arrest and apoptosis of tumor cells following irradiation,while those with mutant or vect p53 genes abrogate this response to irradiation. 野生型p53 基因具有促进照射后肿瘤细胞的G1 期阻滞和凋亡作用，而p53 变异和缺失则减低了肿瘤细胞对放射线的反应。
- Objective To assess the role of the p53 tumor suppressor gene(wild type p53) in G 1 arrest and apoptosis after irradiation in human gastric carcinoma 823 cell lines(BGC823). Methods Three human gastric carcinoma 823 cell lines with different p53 status,i. 目的 评价抑癌基因p53（ 野生型p53） 对照射后人胃癌细胞系（BGC?823） 的G1 期阻滞和凋亡的控制作用。
- The Effects of Wild Type p53 and MDM2 Genes on the Growth of Pancreatic Carcinoma Cells 野生型p53和MDM2基因对胰腺癌细胞生长的影响
- wild type p53 野生型p53
- e. BGC823 wtp53 cells with wild type p53,BGC823 mutp53 cell with mutant p53 alleles and BGC823 vect without p53 gene,were used. Various cell phase distribution and apoptosis were analyzed by flow cytometry in 0,8 and 24h following irradiation with 4Gy. 方法 3 种具有不同p53 状态的人胃癌细胞系，即转染人野生型p53 基因的BGC?823?wtp53 细胞、转染人突变型p53 基因的BGC?823?mutp53 细胞和转染无p53 基因的空载质粒的BGC?823?vect 细胞，用流式细胞计分析细胞，4Gy 照射后0、8 和24 小时后各细胞时相分布和凋亡的反应。
- It would show the same capacity as the wild type. 其能力与野生型相同。
- Phenotypically wild type yeast may be produced. 有可能产生野生种表现型的酵母菌.
- After the infection, the p53 null HCC cell line, Hep3B was most vulnerable to dl1520 induced cytotoxic effect with a cell death rate of more than 60%. Whereas, less than 20% PLC/PRF/5 (p53 mutant) and HepG2 (p53 wild type) HCC cell lines were killed. p5 3基因缺失的肝癌细胞Hep3B对dl15 2 0诱导的细胞毒性作用最敏感 ,超过 6 0%25的细胞被杀伤 ,而不足2 0%25的PLC/PRF/ 5 (p5 3基因突变型 )和HepG2 (p5 3基因野生型 )肝癌细胞被杀伤。
- It would show much higher capacity compared to the wild type. 其能力较野生型高。
- It would show much lower capacity compared to the wild type. 其能力较野生型低。
- The wild type and mutants SMI Cy/Pm,SMI Cy/+,and vg/vg were investigated. 我们对野生型和突变型SM_1Cy/Pm,SM_1Cy/+和+/Pm进行了研究。
- GTT, ITT and BMD showed no difference between wild type and mutant mice. BMD检测亦显示该小鼠在基础状态下无骨密度低下的现象。
- Compared with wild type mice,there was no significant difference in CBF,CPS and ATP levels in L1 KO mice(P>0.05). 与野生型小鼠相比;L1 KO小鼠局部脑血流量、ATP含量和蛋白质合成率差异均无统计学意义(均P>0.;05)。
- The result showed that biofilm formation in agr group I mutant was significantly higher than that in wild type. agr在葡萄球菌中呈多态性。
- Methods:The plasmid pcDNA3 containing the wild type p16 gene and neo gene was used in the transfection experiment. 方法：采用pcDNA3质粒进行转染，该质粒含有野生型P16基因片段和新霉素抗性基因。
- The researchers said the wild type of KRAS is found in around 65 per cent of colorectal cancer patients. 研究者说大约65%25的直肠癌患者的KRAS基因是野生型的。
- There are annual or perennial buckwheat, Tartary Buckwheat and buckwheat wild type wings. 有一年生或多年生的甜荞、苦荞和野翅荞类型。
- The anti-ADH serum prepared by immunization with the ADH preparation from the wild type strain of B. subtilis can neutralize both ADH and GDH. 由枯草杆菌野生型菌株的ADH制剂所制备的抗ADH抗血清能中和ADH与GDH。
- Reocclusionoccured in 50% of rabbits given wild type r-Sak(3/6) while no reocclusion wasobserved in 0.15 mg/kg or 0.30 mg/kg DGR groups. r-Sak 组再栓发生率为 50%25(3/6),而 DGR 高低剂量组均未见再栓(0/6)。 给药后 60min 和 120min,DGR 高剂量组血小板聚集率分别下降了 30%25和 20%25,DGR 低剂量组下降了 21%25和 14%25, 而生理盐水组和 r-Sak 组无显著变化。
- The expressive characteristics of LeETR1 mRNA in tomato mutant Epi and its wild type VFN8 have been studied with RNase protect assay(RPA). 采用核酸酶保护分析 (RPA)方法对番茄乙烯过表达单基因突变体Epi和野生型VFN8中LeETR1mRNA的表达特征进行了研究。
- 今日热词
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- 深远海浮式风电平台 - deep-sea floating wind power platform
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- 京雄高速公路 - Beijing-Xiongan expressway
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- 农业及相关产业增加值 - the added value of agriculture and related industries
