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- Wild type p53 genes promote G 1 phase arrest and apoptosis of tumor cells following irradiation,while those with mutant or vect p53 genes abrogate this response to irradiation. 野生型p53 基因具有促进照射后肿瘤细胞的G1 期阻滞和凋亡作用，而p53 变异和缺失则减低了肿瘤细胞对放射线的反应。
- Biological effects of exogenous wild?type p53 gene on human lung adenocarcinoma cell line GLC?82 外源性野生型p53基因对人肺腺癌细胞系GLC-82的生物学效应
- wild - type p53 gene 野生型p53基因
- e. BGC823 wtp53 cells with wild type p53,BGC823 mutp53 cell with mutant p53 alleles and BGC823 vect without p53 gene,were used. Various cell phase distribution and apoptosis were analyzed by flow cytometry in 0,8 and 24h following irradiation with 4Gy. 方法 3 种具有不同p53 状态的人胃癌细胞系，即转染人野生型p53 基因的BGC?823?wtp53 细胞、转染人突变型p53 基因的BGC?823?mutp53 细胞和转染无p53 基因的空载质粒的BGC?823?vect 细胞，用流式细胞计分析细胞，4Gy 照射后0、8 和24 小时后各细胞时相分布和凋亡的反应。
- Objective To assess the role of the p53 tumor suppressor gene(wild type p53) in G 1 arrest and apoptosis after irradiation in human gastric carcinoma 823 cell lines(BGC823). Methods Three human gastric carcinoma 823 cell lines with different p53 status,i. 目的 评价抑癌基因p53（ 野生型p53） 对照射后人胃癌细胞系（BGC?823） 的G1 期阻滞和凋亡的控制作用。
- Gene mutations in p53 gene exon 11 were identified in all samples,which had the same type and site. p53基因外显子11在所有的被检测样本中均发现突变,而且突变的位点及突变的类型均相同。
- P53 gene is localized in the short arm of human chromosome 17. P53基因定位于人类第17号染色体的短臂，野生型P53基因是肿瘤抑制基因。
- The scientists measured mutations in the P53 gene,the most frequently mutated gene in human cancer. 科学家们对P53基因的突变体进行了测量，该基因是人类患癌症时最经常发生突变的基因。
- The scientists measured mutations in the p53 gene, the most frequently mutated gene in human cancer. 科 学 家 们 对 P53基 因 的 突 变 体 进 行 了 测 量 ， 该 基 因 是 人 类 患 癌 症 时 最 经 常 发 生 突 变 的 基 因 。
- The results of PCR-SSCP analysis showed that 2 out of 4 SPA with abnormal exon 8 of p53 gene. PCR-SSCP分析显示,本研究的4例涎腺多形性腺瘤组织中,2例出现第8外显子异常电泳带; 1例出现第6外显子异常条带。
- Conclusbo: It suggsts that ras gene aed p53 gene mutation may be related with L- form infedtbo. 结合提示L型感染参与了ras原癌基因激活和p53抑癌基因的失活。
- AIM:To explore gene mutations of p53 gene in samples of keloid pedigrees and the relation of keloid onset. 目的:探讨瘢痕疙瘩家系样本有无p53基因突变以及与瘢痕疙瘩发病的关系。 方法:实验标本来自南方医科大学南方医院整形外科2005年收集的A和B两个瘢痕疙瘩家系。
- Methods :P53 gene mutation patterns in 20 cases of HCC by polymerase chain reaction (PCR) and PCR prod-ucts sequencing. 方法:应用多聚酶链式反应(PCR)结合PCR产物测序,同时检测肝癌P53蛋白表达。
- The high mutation rate of p53 gene may indicate that PSH has potentially malignant biological behavior. p53基因的高突变率提示PSH可能具有潜在的恶性生物学行为。
- Mutations in P53 gene or interactions of wild-type p53 protein with E6 protein synthesized by HPV may result in SCCL. P53基因突变或野生型P53蛋白与HPV合成的E6蛋白结合可能会导致肺鳞癌的发生。
- A comparative study on p53 gene mutation in primary human Dukes C col on cancer with that in matched lymph node metastasis. Dukes C期大肠癌原发灶与淋巴结转移灶中p53基因突变的比较
- Objective To ascertain the feasibility of detecting p53 gene mutations for early diagnosis of lung cancer using spu-tum from postbronchoscopy. 目的 探讨纤支镜后痰液标本的p53基因突变检测用于肺癌早期诊断的可行性。
- In 29 cases of ocular adnexal MALT-type, the expression of Ki-67 and p53 gene protein did not correlate with age,sex and location(P >0.05). 29例眼附属器MALT型淋巴瘤在不同的年龄、性别、发病部位Ki-67和p53表达差异无显著性。
- Conclu-sion The above results indicate the value of detecting p53 gene mutation for diagnosis of lung cancer using postbronchoscopic spu-tum. 结论 纤支镜后痰标本p53突变检测对肺癌的早期诊断具有一定价值，可作为肺癌早期诊断的辅助方法之一。
- The Effects of Wild Type p53 and MDM2 Genes on the Growth of Pancreatic Carcinoma Cells 野生型p53和MDM2基因对胰腺癌细胞生长的影响
