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- Study on transcriptional machinery and transcriptional regulation of gene in prokaryotic organisms. 原核生物转录机器及基因转录调控的研究;
- CREB as a transcriptional regulation factor in eucaryotic cell carrie s out the function by itself phosphorylation. CREB是一种细胞核内调控 因子,它通过自身磷酸化实现调节转录的功能。
- DNA methylation has an important role in transcriptional regulation, togethering with histone modification and chromatin remodeling. DNA甲基化在基因转录过程中扮有重要角色,并与组蛋白修饰、染色质构型重塑共同参与转录调控。
- Their analysis indicated that ncRNA has an independent transcriptional regulation system which is different from that of protein coding genes. 他们的研究结果显示非编码RNA基因与蛋白质编码基因各自有一套独立的转录调控系统。
- This study was initiated with the goals of furthering the study of mammalian transcriptional regulation and analyzing the relative benefits of related computational methodologies. 本研究着眼于哺乳动物转录调控并分析比较几种相关的计算方法。
- The 35 papers accorded with the inclusive criteria were about transcriptional regulation of ESCs, Nanog gene and ESCs, Nanog gene and p53, Nanog gene and human, etc. 符合纳入标准的35篇文献中,分别涉及胚胎干细胞的转录调节、Nanog基因与胚胎干细胞、Nanog基因与p53、Nanog基因与人类等方面的内容。
- RNF4 has been implicated in transcriptional regulation through interacting with a variety of nuclear proteins, and functions as a transcriptional corepressor or coactivator. RNF4被认为是转录机制中的协同抑制因子或是活化因子。
- Purpose: High mobility group box-1(HMGB1) was identified as a DNA-binding protein that functions as a cofactor for proper transcriptional regulation in somatic cells. 目的: 高迁移率族蛋白-1(HMGB1)被认为是一种DNA结合蛋白,作为辅助因子协助体细胞进行合适的转录调节。
- In summary, we here report that cyclin D3/CDK11p58 signaling is involved in the transcriptional regulation in eukaryotic cells as well as the cell cycle regulation. 综上所述,我们发现cyclin D3/CDK11p58信号途径除能调控细胞周期外,也参与了真核细胞的转录调控。
- Recent progress has been made in understanding of gene expression, transcriptional regulation and signal transduction in plant responses to drought on the molecular level. 目前,随着现代分子生物学的发展,从分子水平上初步揭示了干旱胁迫信号应答、信号传导及基因表达调控遗传机理。
- A large amount of evidence has implicated BRCA1 in multiple cellular functions including DNA damage response, transcriptional regulation, and control of centrosome duplication. 有大量的证据表明BRCA1具有有很多功能,包括DNA损伤反应,转录调控和控制中心体的复制。
- Taken together, these results significantly advance the understanding of mechanisms that permit fine-tuning of transcriptional regulation by revealing that the hSAGA histone acetyltransferase complex is also capable of histone deubiquitylation. 综上所述,这些结果披露了hSAGA组蛋白乙酰转移酶复合物同时也具有将组蛋白去泛素化的能力,因而大大增进了人们对转录调节过程的精微调节机制的理解。
- Moreover, results of the site-directed mutagenesis of a C-repeat/DRE and two APE-like motifs in a promoter-like region (?630/?308) suggested that two APE-like motifs might be essential for transcriptional regulation of the bkt gene. 对其启动子类似区(-630/-308)中两种功能元件的定点突变结果发现 APE-like(蓝光调控元件)对于 bkt 基因自身的转录可能存在影响。
- The latest progress in molecular mechanisms for transcriptional regulation of 9oncogenes (c-myc, c-fos, c-jun, ETS-2, c-myb, c-erbB_2/neu, c-Ha-ras, c-Ki-ras, c-rel) and2 tumor suppressor genes (Rb, p53) was reviewed. 概述了9种癌基因(c-myc、c-fos、c-jun、ETS-2、c-myb、c-erbB_2/neu、c-Ha-ras、c-Ki-ras、c-rel)和2种抑癌基因(Rb、p53)转录调控的分子机制研究在近年来所取得的主要进展。
- The abnormality of signal transduction and transcriptional regulatory protein is considered as two... 目前认为,信号转导和转录调节蛋白的异常是与之相关的两个可能因素。
- These data provide a new clue to understand the new role of Cyclin D3 as a transcriptional regulator. 这为我们深入了解Cyclin D3的转录调控功能提供了一条新的线索。
- Many findings suggest that THAP proteins may function as sequence-specific DNA-binding factors with roles in cell proliferation, apoptosis, chromatin modification, and transcriptional regulation. 研究表明这是一类锌离子依赖的DNA结合蛋白,广泛参与细胞增殖、凋亡调控,并可能与染色体修饰/重构相关。
- We will discuss the importance of chromatin structure in contemporary modeling, and review recent research results on the relationship between chromatin structure and transcriptional regulation. 我们会讨论在当代的模型化里染色质结构的重要性,并且温习在染色质结构和转录调控之间关系上,当前的研究工作成果。
- Detecting the transcriptional regulatory elements is the key of understanding the transcriptional regulatory mechanism and gene expression pattern. 识别转录调控元件是理解基因转录机制和表达模式的关键。
- In this module we will build predictive models of transcriptional regulatory networks using probabilistic modeling techniques. 在这模块,我们将使用几率模型技术,构建预测的转录调控网络模型。