Taken together, these results significantly advance the understanding of mechanisms that permit fine-tuning of transcriptional regulation by revealing that the hSAGA histone acetyltransferase complex is also capable of histone deubiquitylation.

• 综上所述,这些结果披露了hSAGA组蛋白乙酰转移酶复合物同时也具有将组蛋白去泛素化的能力,因而大大增进了人们对转录调节过程的精微调节机制的理解。