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- Thiopurine methyltransferase (TPMT) plays an important role in the metabolism of 6-MP.This article reviews the literature on the role of TPMT measurement prior to treatment of IBD with AZA/6-MP. 硫嘌呤甲基转移酶(TPMT)是6-MP代谢的关键酶，本文综述IBD患者用AZA/6-MP治疗前检测TPMT的临床意义。
- Thiopurine methyltransferase(TPMT) plays an important role in the metabolism of 6-MP.This article reviews the literature on the role of TPMT measurement prior to treatment of IBD with AZA/6-MP. 硫嘌呤甲基转移酶(TPMT)是6-MP代谢的关键酶,本文综述IBD患者用AZA/6-MP治疗前检测TPMT的临床意义。
- Keywords thiopurine methyltransferase;genetic polymorphism;activity;genotype; 巯嘌呤甲基转移酶;遗传多态性;活性;基因型;
- Keywords thiopurine methyltransferase（TPMT）;6-mercaptopurine;azathioprine;pharmacokinetics; 巯嘌呤甲基转移酶;6-巯基嘌呤;硫唑嘌呤;药动学;
- HPLC assay of thiopurine methyltransferase activity inhuman red blood cells from adult with a cute lymphoblastic leukemia 高效液相色谱法测定急性淋巴细胞白血病患者巯嘌呤甲基转移酶活性
- Determination of human red blood cell thiopurine methyltransferase activity by high-performance liquid chromatographic method 高效液相色谱法测定人红细胞中巯基嘌呤甲基转移酶的活性
- thiopurine methyltransferase 硫代嘌呤甲基转移酶
- Some of this damage can be repaired by the DNA methyltransferase MGMT. 这类损伤中有一部分可被DNA甲基转移酶MGMT所修复。
- In vitro activity assays confirmed that recombinant OsSET3 was a functional H3K9 methyltransferase while OsSET2 and OsSET4 were not. 利用大肠杆菌表达的OsSET2、OsSET3和OsSET4重组蛋白进行的体外活性检测实验证明OsSET3具有组蛋白H3K9的甲基转移酶活性，而OsSET2和OsSET4不具有该活性。
- The massive researches on histone methyltransferase and effector proteins in recent years have increased our understanding of H3K4 methylation. 随着对组蛋白甲基化转移酶及相关作用蛋白研究的深入,人们对组蛋白H3第4赖氨酸的甲基化的功能也有了更深的了解。
- Objective To explore the role of protein expression of DNA methyltransferase 1(DNMT1) in lung adenocarcinoma carcinogenesis and prognosis. 目的检测肺腺癌中DNA甲基转移酶1(DNMT1)蛋白水平的表达,探讨其在肺腺癌发生中的作用及其预后价值。
- They found that HP1 proteins, which bind to methylated histones, also interact with the DNA methyltransferase, DNMT1, to stimulate its DNA methylation actiity. 他们还发现与甲基化组蛋白相结合的Hp1蛋白和DNA甲基转移酶（DNMT）即DNMT1之间也存在相互作用，它可激发DNA甲基化活性。
- Objective:To detect the expression of O6-methylguanine-DNA methyltransferase (MGMT),and it s effect of promoter hypermethylation on tumorigenesis and progression. 目的:检测大肠癌组织中O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)的表达情况及其在肿瘤发生发展中的作用和临床意义。
- Comparing to Candida albicans and Sacchromyces cerivisiae sterol methyltransferase,A. fumigatus Erg6p had 57% and 50% identity, and had 70% and 63% similarity in amino acid sequences,respectively. 其编码的蛋白与白念珠菌、酿酒酵母固醇甲基转移酶(Ers6p)的氨基酸相同率分别为57%25和50%25,相似率分别为70%25和63%25。
- DNA methyltransferase inhibitor 5-Aza-CdR can induce demethylation in the promoter region of RASSF1A. It can also reverse epigenetic transcriptional silencing caused by methylation and induce the re-expression of RASSF1A in QBC-939. DNA甲基转移酶抑制剂5-Aza-CdR能够诱导RASSF1A基因启动子区域去甲基化,并通过该机制诱导RASSF1A基因在人胆管癌细胞系QBC-939中的表达。
- To test whether DNA methylation plays a role in somaclonal variation, the calli were treated with 5-azacytidine that reduces cytosine methylation by blocking activity of DNA methyltransferase. 为了检测DNA甲基化在体细胞克隆多样性中的作用，愈伤组织用5-氮胞苷进行处理，5-氮胞苷通过抑制DNA甲基转移酶的活性降低胞嘧啶的甲基化水平。
- O6-Methylguanine-DNA methyltransferase(MGMT)is an important DNA repair gene in human cells.It plays an important role in resisting cellular DNA damage induced by alkylating agents. O6甲基鸟嘌呤DNA甲基转移酶(MGMT)是细胞中一种重要的DNA损伤修复酶,它在抵御烷化剂所致的细胞突变和死亡中起重要作用。
- Modulation of O6-methylguanine-DNA methyltransferase(MGMT) and mismatch repair(MMR) expression in tumors and normal tissue is currently being investigated as a possible strategy ... 靶向DNA修复机制增强抗肿瘤化疗药物的疗效、克服肿瘤耐药正成为肿瘤个体化化疗研究的一个重要领域。
- Thiopurine methytransferase gene 巯嘌呤甲基转移酶基因
- ribosomal protein L11 methyltransferase 钩端螺旋体甲基化转移酶
