Thiopurine methyltransferase (TPMT) plays an important role in the metabolism of 6-MP.This article reviews the literature on the role of TPMT measurement prior to treatment of IBD with AZA/6-MP.

• 硫嘌呤甲基转移酶(TPMT)是6-MP代谢的关键酶，本文综述IBD患者用AZA/6-MP治疗前检测TPMT的临床意义。