substantial connection的用法和样例：
例句
- The closeness of their connection with the church made them adopt a slightly dictatorial attitude to the rest of mankind.
他们同教会的密切关系，使她们对其他人采取一种有些高人一等的气势。 - This paper reviews the close connection of senescence and pertinent pathological changes with cell signal transductions which have brought obstacles or abnormity.
概述了衰老及相关病变与细胞信号转导障碍或异常的密切关系。
