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- Roles of receptor tyrosine kinases, integrins, and Shc. 外文期刊 Mechanotransduction in response to shear stress.
- The inhibitor of VEGF receptor tyrosine kinase was introduced in detail. 详细介绍了VEGF受体酪氨酸激酶抑制剂的研究进展。
- Sunitinb is a novel multitargeted receptor tyrosine kinase inhibitor. 苏尼替尼是一种新型的多靶点酪氨酸激酶抑制剂。
- Objective.Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a member of the PTPs that negatively regulate T-cell activation. 目的：蛋白酪氨酸磷酸酶非受体型22（Protein tyrosine phosphatase non-receptor type 22，PTPN22）是T细胞激活的抑制性调节分子。
- SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase is involved in the signaling pathways of a variety of growth factors and cytokines. SHP-2，一种含有SH2区域的胞浆蛋白酪氨酸磷酸酶，参与了各种生长因子和细胞因子的信号传导过程。
- Objective:To explore the mutation of receptor tyrosine kinase ( RET ) gene in sporadic medullary thyroid carcinoma. 目的:研究散发型甲状腺髓样癌酪氨酸激酶受体基因(RET)的突变情况。
- Angiopoietin acts on Tie-2,which is a receptor tyrosine kinase specifically expressed on endothelial cells. 作用于内皮特异受体酪氨酸激酶酪氨酸激酶受体2。
- We are interested in the identification of novel components in Drosophila EGF receptor tyrosine kinase (RTK) signal transduction pathway. 我们主要的兴趣在于用遗传学及分子生物学的方法来研究果蝇的胚胎发育过程。
- All these actions of VEGF are mediated by receptor tyrosine kinase, vascular endothelial growth factor receptor (VEGFR). 所有这些作用都是通过血管内皮生长因子受体信号转导通路实现的。
- Objective To investigate the expression level of Shp-2 tyrosine phosphatase in chronic myeloid leukemia (CML) and its relationship with the unlimited growth and apoptosis resistance of p210 bcr/abl-induced malignant cells. 目的研究Src癌基因同源的酪氨酸蛋白磷酸酶2(Shp2)在慢性粒细胞白血病(CML)细胞中的表达,及其在p210bcr/abl诱导的白血病细胞恶性增殖和凋亡抵抗中的作用。
- The outcome is the absolutely deficit of insulin in the body.Some autoantigen including insulin,glutamate decarboxylase and tyrosine phosphatase maybe targeted antigen triggering t... 一些自身抗原如胰岛素、谷氨酸脱羧酶和酪氨酸磷酸酶等可能是触发该自身免疫反应的靶抗原,而细胞因子、趋化因子及炎性介质等亦参与了该免疫过程。
- This article reviewed classification, structure and functions of receptor tyrosine protein kinase as well as the progress of some relative cell transduction mechanisms. 本文主要介绍生长因子受体酪氨酸蛋白激酶的分类、结构与功能及其部分相关信号转导机制的研究进展。
- The 8 new mutations included three in genes that normally suppress the growth of tumor cells, one being the PTPRT tyrosine phosphatase gene, which is sometimes found mutated in colon cancer. 8个新的突变位点中，有3个基因通常起到抑制肿瘤细胞生长的功能，另外一个PTPRT酪氨酸磷酸酶基因在结肠癌中会发生突变。
- The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases have close connection with the initiation, progression and progn osis of various malignancies. 表皮生长因子受体(EGFR)家族的受体酪氨酸激酶与多种恶性肿瘤的发生、发展及预后等密切相关。
- Receptor tyrosine kinase (RTK), a membrane receptor superfamily with intrinsic protein tyrosine kinase activity, has many members and complicated signal transduction pathways. 摘要受体酪氨酸激酶是一个具有内在酪氨酸蛋白激酶活性的膜受体超家族，成员众多，信号转导通路复杂多样。
- Moreover, non-cytotoxic agents such as small molecules targeting receptor tyrosine kinases and intracellular signaling pathways have been used in the clinical field. 替莫唑胺及亚硝基脲类药物耐药性得到了部分解决以及非细胞毒性药物如酪氨酸激酶抑制剂及细胞间信号传导通路抑制剂在临床中的应用。
- Receptor tyrosine protein kinase is one of key kinases in cell signal transduction and plays an important role in the process of cell growth, development and functions regulated by growth factors. 受体酪氨酸蛋白激酶是细胞信号转导进行的关键信号酶,在生长因子调控细胞生长、发育与功能的过程中起着重要的生理作用。
- However, the role of specific protein tyrosine phosphatases (PTPs) in these pathways is unknown. 然而，在这些途径中，特异性酪氨酸蛋白激酶的作用尚未清楚。
- Objective To construct the antisense nucleic acid eukaryotic expressing vector of the cDNA sequence encoding the transmembrane domain of receptor tyrosine kinase RON (RON-RTK) gene (RONm). 目的构建RON基因跨膜区段(RONm)的反义核酸真核表达载体。
- Sorafenib, a novel, oral multi-kinase inhibitor, targets on serine/threonine and receptor tyrosine kinases of the tumor cells and vasculature; blocks the signal transconduction and inhibits tumor growth. 摘要索拉非尼是首个口服多激酶抑制药，靶向作用于肿瘤细胞和肿瘤血管上的丝氨酸和（或）苏氨酸及受体酪氨酸激酶，阻断信号传导，抑制肿瘤生长。
