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- Wild type p53 genes promote G 1 phase arrest and apoptosis of tumor cells following irradiation,while those with mutant or vect p53 genes abrogate this response to irradiation. 野生型p53 基因具有促进照射后肿瘤细胞的G1 期阻滞和凋亡作用,而p53 变异和缺失则减低了肿瘤细胞对放射线的反应。
- p53 gene promoter p53基因启动子
- P53 gene is localized in the short arm of human chromosome 17. P53基因定位于人类第17号染色体的短臂,野生型P53基因是肿瘤抑制基因。
- Positive genotype of RANTES gene promoter -28G may be related to DN. RANTES基因启动子-28G阳性基因型可能与糖尿病肾病相关。
- The scientists measured mutations in the P53 gene,the most frequently mutated gene in human cancer. 科学家们对P53基因的突变体进行了测量,该基因是人类患癌症时最经常发生突变的基因。
- The scientists measured mutations in the p53 gene, the most frequently mutated gene in human cancer. 科 学 家 们 对 P53基 因 的 突 变 体 进 行 了 测 量 , 该 基 因 是 人 类 患 癌 症 时 最 经 常 发 生 突 变 的 基 因 。
- The results of PCR-SSCP analysis showed that 2 out of 4 SPA with abnormal exon 8 of p53 gene. PCR-SSCP分析显示,本研究的4例涎腺多形性腺瘤组织中,2例出现第8外显子异常电泳带; 1例出现第6外显子异常条带。
- Partial Deleted Complementary Sense Gene Promoter from Cotton Leaf Curl Virus Shows Super Strong Promoter Activity. 部分缺失的棉花曲叶病毒互补链基因启动子具有超强活性。
- Conclusbo: It suggsts that ras gene aed p53 gene mutation may be related with L- form infedtbo. 结合提示L型感染参与了ras原癌基因激活和p53抑癌基因的失活。
- The methylation specific PCR (MSP) and bisulfite DNA sequencing were performed to examine the methylation status of SLIT2 gene promoter. 亚硫酸氢钠处理DNA,用MSP和测序法检测SLIT2启动子甲基化状态。
- AIM:To explore gene mutations of p53 gene in samples of keloid pedigrees and the relation of keloid onset. 目的:探讨瘢痕疙瘩家系样本有无p53基因突变以及与瘢痕疙瘩发病的关系。 方法:实验标本来自南方医科大学南方医院整形外科2005年收集的A和B两个瘢痕疙瘩家系。
- Abstract: BACKGROUND: Gene promoter methylation is an epigenetic eent leading to gene silencing. 摘要:背景:基因启动子甲基化是一种可引起基因沉默的表观遗传事件。
- Methods :P53 gene mutation patterns in 20 cases of HCC by polymerase chain reaction (PCR) and PCR prod-ucts sequencing. 方法:应用多聚酶链式反应(PCR)结合PCR产物测序,同时检测肝癌P53蛋白表达。
- Objective:To construct expression vector of human ID4 gene promoter on the basis of bioinformatics analysis. 目的:基于生物信息学分析构建人ID4基因启动子表达载体,以其作为研究ID4基因启动子表达调控分析的工作基础。
- Gene mutations in p53 gene exon 11 were identified in all samples,which had the same type and site. p53基因外显子11在所有的被检测样本中均发现突变,而且突变的位点及突变的类型均相同。
- Methylation of hMLH1 and COX-2 gene promoter CpG islands may both occur in the development of MSI gastric carcinoma. 在MSI胃癌(尤其是MSI-H型胃癌)的发生、发展过程中可能同时出现了hMLH1和COX-2基因启动子CpG岛的甲基化(即表型遗传修饰)。
- The high mutation rate of p53 gene may indicate that PSH has potentially malignant biological behavior. p53基因的高突变率提示PSH可能具有潜在的恶性生物学行为。
- Methylation of hMSH2 gene promoter CpG islands was not detected in gastric carcinoma or normal tissues. hMSH2基因启动子CpG岛在胃癌及正常组织中均未检测到甲基化。
- Mutations in P53 gene or interactions of wild-type p53 protein with E6 protein synthesized by HPV may result in SCCL. P53基因突变或野生型P53蛋白与HPV合成的E6蛋白结合可能会导致肺鳞癌的发生。
- Isolation and Characterization of CMO Gene Promoter from Halophyte Suaeda liaotungensis K. 辽宁碱蓬胆碱单加氧酶(CMO)基因启动子分离及功能元件分析(英文)