Methylation of hMLH1 and COX-2 gene promoter CpG islands may both occur in the development of MSI gastric carcinoma.

• 在MSI胃癌(尤其是MSI-H型胃癌)的发生、发展过程中可能同时出现了hMLH1和COX-2基因启动子CpG岛的甲基化(即表型遗传修饰)。