major defeat

• 重大挫折

major defeat的用法和样例：

例句

1. The defeat constitutes a major set-back for our diplomacy.
   这次失败是我们外交上的重大挫折。
2. The news I received today is a major setback to my project.
   我今天得到的消息对我的计划是一个重大挫折。