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- Wild type p53 genes promote G 1 phase arrest and apoptosis of tumor cells following irradiation,while those with mutant or vect p53 genes abrogate this response to irradiation. 野生型p53 基因具有促进照射后肿瘤细胞的G1 期阻滞和凋亡作用，而p53 变异和缺失则减低了肿瘤细胞对放射线的反应。
- Objective To assess the role of the p53 tumor suppressor gene(wild type p53) in G 1 arrest and apoptosis after irradiation in human gastric carcinoma 823 cell lines(BGC823). Methods Three human gastric carcinoma 823 cell lines with different p53 status,i. 目的 评价抑癌基因p53（ 野生型p53） 对照射后人胃癌细胞系（BGC?823） 的G1 期阻滞和凋亡的控制作用。
- e. BGC823 wtp53 cells with wild type p53,BGC823 mutp53 cell with mutant p53 alleles and BGC823 vect without p53 gene,were used. Various cell phase distribution and apoptosis were analyzed by flow cytometry in 0,8 and 24h following irradiation with 4Gy. 方法 3 种具有不同p53 状态的人胃癌细胞系，即转染人野生型p53 基因的BGC?823?wtp53 细胞、转染人突变型p53 基因的BGC?823?mutp53 细胞和转染无p53 基因的空载质粒的BGC?823?vect 细胞，用流式细胞计分析细胞，4Gy 照射后0、8 和24 小时后各细胞时相分布和凋亡的反应。
- Biological effects of exogenous wild?type p53 gene on human lung adenocarcinoma cell line GLC?82 外源性野生型p53基因对人肺腺癌细胞系GLC-82的生物学效应
- Preparation and identification of recombinant adenoviral vectors containing human wild type SPK and its mutant gene 携带人鞘氨醇激酶及突变体基因重组腺病毒载体的制备及表达
- Establishment of CHO Cell Line Stably Overexpressing Human Wild Type DNA Polymerase Beta Gene and Its Biological Characteristics 高表达中国仓鼠卵巢细胞系的建立及其生物学特征
- wild - type p53 gene 野生型p53基因
- The Effects of Wild Type p53 and MDM2 Genes on the Growth of Pancreatic Carcinoma Cells 野生型p53和MDM2基因对胰腺癌细胞生长的影响
- P53 gene is localized in the short arm of human chromosome 17. P53基因定位于人类第17号染色体的短臂，野生型P53基因是肿瘤抑制基因。
- wild type p53 野生型p53
- The scientists measured mutations in the P53 gene,the most frequently mutated gene in human cancer. 科学家们对P53基因的突变体进行了测量，该基因是人类患癌症时最经常发生突变的基因。
- It would show the same capacity as the wild type. 其能力与野生型相同。
- Phenotypically wild type yeast may be produced. 有可能产生野生种表现型的酵母菌.
- The scientists measured mutations in the p53 gene, the most frequently mutated gene in human cancer. 科 学 家 们 对 P53基 因 的 突 变 体 进 行 了 测 量 ， 该 基 因 是 人 类 患 癌 症 时 最 经 常 发 生 突 变 的 基 因 。
- A comparative study on p53 gene mutation in primary human Dukes C col on cancer with that in matched lymph node metastasis. Dukes C期大肠癌原发灶与淋巴结转移灶中p53基因突变的比较
- Gene mutations in p53 gene exon 11 were identified in all samples,which had the same type and site. p53基因外显子11在所有的被检测样本中均发现突变,而且突变的位点及突变的类型均相同。
- The mutated P53 protein and mutaion in the sequence of P53 gene were detected simultsneously in BPDE transformed human bronchial epithelium cells. BPDE诱导人气管上皮细胞的转化细胞可同时检测到P53突变蛋白的表达及P53基因序列的突变。
- It would show much higher capacity compared to the wild type. 其能力较野生型高。
- It would show much lower capacity compared to the wild type. 其能力较野生型低。
- Methods:The plasmid pcDNA3 containing the wild type p16 gene and neo gene was used in the transfection experiment. 方法：采用pcDNA3质粒进行转染，该质粒含有野生型P16基因片段和新霉素抗性基因。
