Transgenic or knockout of specific genes have led to the development of rodent models of spontaneous colitis. 转基因和基因敲除动物模型带动了自发性结肠炎动物模型的发展。
This would seem to prevent researchers from making dog "knockouts" lacking a specific gene or engineering dogs that produce mutant forms of a gene. 因为缺少一种特定的基因或能产生突变基因的转基因狗，研究人员可能无法进行狗基因敲除。
Scientists have attempted to treat the disease with gene therapy, whereby the defective gene is swapped for a healthy one. 科学家一直希望用基因疗法治疗此病，即用健康基因把失去功能的基因替换掉。
Twenty percent of those mice, though, developed cancer, illustrating the risk of using retroviruses and a cancer gene to make cells for replacement parts. 但是百分之二十的那些老鼠发展成癌症，这表明了用反转录病毒的危险和在细胞使用肿瘤基因替换部分。
