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- dominant negative regulator 显性抑制调节物, 显性负性调节物
- Overexpression of wild-type E6-AP in vivo enhanced the ubiquitination of TH1, whereas a dominant negative E6-AP mutant inhibits its ubiquitination. 过表达野生型的E6-AP会增强TH1的泛素化;而过表达泛素连接酶活性缺失E6-AP突变体则会抑制TH1的这种泛素化。
- The NF1 tumor suppressor encodes a protein product neurofibromin,which functions as a negative regulator of RAS. NF1为肿瘤抑制基因,是RAS的负向调节器。
- It was found that wtFAK and FAKY576F up-regulated GalT gene expression and its surface activity, while dominant negative mutant FAKY397F down-regulated them. 结果发现wtFAK和FAKY576F上调GalT基因表达和表面酶活性,而FAK的dominant negatiVe突变体FAKY397F下调Galt基因表达和表面酶活性。
- The negative regulator is simply a unity-gain inverter withinput resistor, R6, and feedback resistor, R7. 负电源整流部分就是一个简单的单位增益反相器,输入电阻是R6,反馈电阻是R7。
- Cyclin is the positive regulator which activates CDK and CDK inhibitor (CDKI) is the negative regulator which inactivates CDK. CDK抑制剂(CDKI)则是负调节因子使CDK失活。
- HAMP encodes a kind of small peptide called hepcidin which is a negative regulator of iron absorbtion in the small intestine and iron release from macrophages. HAMP基因编码一种名为海帕西啶的小肽,是小肠铁重吸收和巨噬细胞铁释放的负调节因子。
- Here, we found that overexpression of a dominant negative mutant form of human RPL8 (hRPL8), decreased cell and organ size in multiple Drosophila tissues without affecting cell differentiation. 在本文的第二部分中我们过量表达突变的人类基因RPL8可以在身体各组织中影响细胞大小和器官大小但并不影响细胞分化。
- PTP is a negative regulating factor in the MAPK pathway. MAPK级联途径参与有机体的发育、细胞增殖、激素调节以及逆境胁迫的信号转导, PTP在MAPK级联途径中主要起负调控作用。
- CKI plays a negative regulatory role by inhibiting the activity of cyclin-CDK. 细胞周期调节蛋白在细胞周期中的表达和作用已成为当今研究的热门话题。
- Negative regulation involves the binding of a repressor to the operator to prevent transcription. 在负向可诱导操纵子中,一个调节的阻遏蛋白质一般会与操纵基因结合,并阻止操纵子中基因的转录。若存在着一个诱导物分子,它会与阻遏基因结合,并改变它的构造,使它不能与操纵基因结合。这可以使操纵基因的转录发生。
- It is suggested that flavonoids act as negative regulators of auxin transport in vivo. 植物体内广泛存在的类黄酮类物质影响生长素运输,对生长素运输起负调控作用。
- Keywords HBcAg;dominant negative mutant;green fluorescent protein; 乙肝核心抗原;显性失活突变体;绿色荧光蛋白;
- Dominant negative human telomerase reverase transcriptase gene 人端粒酶逆转录酶显性负突变体
- Peace was the dominant theme of the conference. 和平是大会的首要议题。
- HIR/HIRA,encoded by Hir/Hira(histone regulation) genes,were identified as negative regulators of histone gene expression. H ir/H ira基因产物是组蛋白基因表达的一种负调节因子;其在果蝇发育过程中的作用还没有得到确认.
- The right hand is dominant in most people. 大多数人的右手是优势手。
- While tumor suppressing genes p53 and WT1 present negative roles in hTERT expression, including other negative regulators: MZF-2 and Mad. 另外,p53、WT1、MZF-2和Mad是已知的对hTERT的转录起抑制作用的因子。
- HIR/HIRA, one of the histone chaperones, encoded by Hir/Hira (histone regulation) genes, were initially identified in yeast as negative regulators of histone gene expression. 摘要Hir/Hira基因产物HIR/HIRA为组蛋白的伴侣蛋白,最先作为组蛋白基因表达的一种负调节因子从酵母中被鉴定出来。
- HIR/HIRA,one of the histone chaperones,encoded by Hir/Hira(histone regulation) genes,were initially identified in yeast as negative regulators of histone gene expression. Hir/Hira基因产物HIR/HIRA为组蛋白的伴侣蛋白,最先作为组蛋白基因表达的一种负调节因子从酵母中被鉴定出来。