HIR/HIRA, one of the histone chaperones, encoded by Hir/Hira (histone regulation) genes, were initially identified in yeast as negative regulators of histone gene expression.

• 摘要Hir/Hira基因产物HIR/HIRA为组蛋白的伴侣蛋白，最先作为组蛋白基因表达的一种负调节因子从酵母中被鉴定出来。