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In this paper, recent advances in the Study on chemokines and chemokine receptor antagonists were reviewed. 本文对趋化因子及其受体拮抗剂的研究进展进行综述。
The chemokine receptor CXCR6 and its ligand CXCL16 are involved in inflammation. 趋化因子受体CXCR6 及其配体CXCL16的作用是参与炎症。
The molecular evolutionary rates of chemokine receptor genes are different, with CXCR4 gene scored the lowest. 趋化因子受体的进化速率不同，其中CXCR4的进化速率最低。
Abstract： Objective To explore the correlation between structure domains and function of chemokine receptor CXCR4. 摘要：目的认识趋化因子受体CXCR4之结构与功能的关系。
The aim of this article is to review recent devel-opment of CCR7,a newly identified chemokine receptor,and its ligand CCL21and CCL19. 全文就新近发现的趋化因子受体CCR7及其配体CCL21和CCL19的研究进展作一综述。
Objective To investigate whether homocysteine (HCY) can induce the expression of chemokine receptor CCR1 mRNA in cultured THP-1 monocytes. 目的探讨同型半胱氨酸对人单核细胞株THP 1表达趋化因子受体CCR1mRNA的影响。
Objective To investigate the role of CC chemokine receptor 5(CCR5) in the immunological pathogenesis of hepatitis B(HB). 目的研究细胞趋化因子受体5(CCR5)在乙型病毒性肝炎(HB)免疫发病机制中的作用。
AIM:To investigate the expression of CC chemokine receptor 7 (CCR7) in different types of lung carcinoma and its clinical significance. 目的:探讨趋化因子受体CCR7在不同类型肺癌组织中的表达及其临床意义。
Chemokine CCL21 is a ligand of chemokine receptor (CCR)7. It is constitutively expressed at high level in secondary lymphoid organs (thymus, lymph node, spleen). 趋化因子CCL21是趋化因子受体(CCR)7的一个配体。它在次级淋巴器官(胸腺、淋巴结、脾脏)中组成性高表达。
Objective To explore the relationship between chemokine receptor CCR5, CCR2 gene polymorphism and Chinese type 1 diabetics, as well as their first relatives. 目的探讨趋化因子受体CCR2、CCR5基因多态性与 1型糖尿病 (T1DM)及其一级亲属之间的关系 ,并与T2DM及非DM对照进行比较。
Thymus and activation -regulated chemokine (TARC) , a CC chemokine, was identified as a selective chemoattractant for CC chemokine receptor 4 (CCR4) - expressing cells to ti-uss. 胸腺和活化调节趋化因子(thymus and activation-regulated chemokine，TARC)是CC型趋化因子，其受体是CC趋化因子受体4(CC chemokine receptor 4，CCR4)，在活化的Th2细胞上呈优势表达，它们共同作用使Th2细胞由血液迁移到一定的组织中。
Chemokines are chemotactic cytokines that can direct cells trafficking,conducting their functions via chemokine receptors. 趋化因子是控制细胞定向迁移的细胞因子,其功能由趋化因子受体介导。
To investigate the expression of chemokine receptor CCR7 in peripheral lymphocytes of gastric carcinoma and its relationship with clinicopathological characteristics. 目的研究趋化因子受体CCR7在胃癌患者外周血淋巴细胞各亚群的表达，并与健康人进行比较，探讨其与临床病理分期之间的相关性。
Chemokines are chemotactic cytokines that can direct cells trafficking, conducting their functions via chemokine receptors. 趋化因子是一类控制细胞定向迁移的细胞因子。
Chemokines are chemotactic cytokines that can induce immune cells migration, conducting their functions via chemokine receptors. 趋化因子是一类控制免疫细胞定向迁移的细胞因子, 其功能行使由趋化因子受体介导。
The similarity between the virus encoded chemokines or chemokine receptors with those of host genes is a consequence of evolutionary mimicry. 病毒编码与寄主相似的趋化因子或受体是进化过程中分子模拟的结果。
In this study, the phylogenetic trees of chemokines and chemokine receptors are produced, based on distance parsimonious method, using avaliable amino acid sequences from GenBank. 摘要通过分析现有的趋化因子和趋化因子受体的氨基酸序列,用距离法和最简约法构建了聚类图,探讨了趋化因子和趋化因子受体基因家族的系统演化特征。
Moreover,different profile of chemokines and chemokine receptors is always found in these diseases,suggesting that there are some relationship between sex hormones and chemokines. 研究证实性激素对趋化因子表达、分泌与活性的调节是广泛而多样的,其作用可因趋化因子的种类、组织和细胞的不同而异。
This review focuses on recent advances in understanding the CD4+ CD25+ regulatory T cells, chemokine and receptor, chemokine receptor expressing on CD4+ CD25+ Tr cells and the attraction of these cells by antigen presenting cells (APCs). 了解CD4+CD25+Tr细胞、趋化性细胞因子、趋化性细胞因子受体和表达于CD4+CD25+Tr细胞上的趋化性细胞因子受体以及它们与不同的抗原提呈细胞(APCs)之间的作用的最新研究进展十分必要。
To explore the role of the autoantibodies(GADA,IAA,ICA), the polymorphisms of chemokine receptor CCR5 , CCR2 , and the expression of CD4+CCR5+ and CD4+CCR3+ in the PBMC of the type 1 diabetes mellitus in prediction and diagnosis type 1 diabetes. 检测1型糖尿病患者的血清自身抗体水平、趋化因子受体CCR5、CCR2的基因多态性，以及趋化因子受体CCR5、ECR3在1型糖尿病患者外周血CD4~+T淋巴细胞中的表达水平，研究这些检测指标对1型糖尿病早期预报和早期诊断的意义。

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