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- Western blot analysis suggested the decreased cell motility might be attributed to the reduced phosphorylation of focal adhesion kinase (FAK) by PTEN gene delivery. 利用西方墨点法分析可以推测经PTEN基因传送的肝癌细胞移行数目的减少,可能是因降低了FAK磷酸化的缘故所致。
- Human Epithelial Cell Adhesion Molecul... 人上皮细胞粘附分子(Ep-CAM/CD362)试剂盒;
- PURPOSE: To investigate the expression of focal adhesion kinase(FAK) and PTEN in salivary adenoid cystic carcinoma(SACC)and its significance. 摘要目的:探讨黏着斑激酶(FAK)和PTEN基因蛋白在腺样囊性癌组织中的表达及意义。
- FAK (focal adhesion kinase) is a non-receptor tyrosine kinase that is widely expressed in vivo and highly conserved in structure. 粘着斑激酶是一种在体内广泛表达且结构高度稳定的非受体型酪氨酸激酶。
- Focal adhesion kinase (FAK) is the intermediator linking integrins to downstream signal proteins, and plays a key role in multiple signal pathways. 粘着斑激酶(focal adhesion kinase,FAK)则是整合素信号途径中连接整合素与下级信号分子的媒介,是胞内多条信号途径的交汇点。
- To study the effect of antisense focal adhesion kinase (FAK) oligodeoxynucleotide on the biological behaviors of U251 MG cells. 目的探讨反义黏着斑激酶(FAK)对U251人胶质瘤细胞株生物学行为影响。
- The majority of integrin signaling proceeds through focal adhesion kinase (FAK), an essential component of the focal adhesion complex. 大部分整合素的信号传导是通过一种灶性附着复合体的必需物质--灶性粘附激酶实现的。
- Another area of current interest concerns the possible role of cell surface glycoproteins in cell adhesion. 近来有兴趣的另一领域是关于细胞表面糖蛋白在细胞的粘附中可能起的作用。
- Objective The study investigated the effect of gastrin on tyrosine phosphorylation and protein expression of focal adhesion kinase (FAK) in human colon cancer cells. 目的研究胃泌素对人结肠癌细胞信号分子黏着斑激酶(FAK)酪氨酸磷酸化和蛋白质表达的影响。
- The expression and activity of the focal adhesion kinase on cultured Raji cells were regulated by Triptolide,and this regulation may be important in the tumor-pathogesis. 雷公藤内酯醇具有抗淋巴瘤细胞增殖效应,并同时降低FAK含量和活力,提示雷公藤内酯醇抗肿瘤效应可能与抑制黏着斑激酶介导细胞信号转导有关。
- Cell adhesion activity of CEA on tumor cell lines was studied in the experiment. 本实验对肿瘤细胞系的癌胚抗原(ea)胞粘附活性进行了研究。
- These improvements further the applications of BFP in the field of cell adhesion. 这些拓展了生物膜力探针的应用范围。 本文建立的方法学对于认识细胞粘附具有一定的意义。
- These molecules can promote cell adhesion and migration and are believed to play a role in tumor cell invasion. 细胞表面糖链通过与肿瘤细胞凝集素结合参与细胞间的作用。 因此,肿瘤细胞与基膜成份的粘着,肿瘤细胞间、肿瘤细胞与宿主细胞的粘合是癌转移过程中的重要步骤。
- E-cadherin, as a cell adhesion molecule containing high mannose type N-linked glycan, mediates homotypic cell adhesion. E-钙粘蛋白作为含有高甘露糖型N-糖链的细胞粘附分子,介导着细胞间的嗜同性粘附。
- Cell adhesion forces were measured by means of micropipette aspiration technique. 细胞粘附力采用微管吸吮技术进行测定。
- Cell adhesion has a vital effect on renal inflammatory injury, renal tubular lesions and interstitial fibrosis. 其在肾脏炎性病变、肾小管损伤、肾间质纤维化等发生发展中起重要作用。
- FAK(focal adhesion kinase) discovered by Schaller is a major substance which can be activated by src-ingeneration protein-tyrosine kinase and it is a non-receptorprotein-tyrosion kinase. 黏着斑激酶(focal adhesion kinase,FAK)是Schaller等发现的能被scr内源性蛋白酪氨酸激酶激活的主要底物,属于非受体蛋白酪氨酸激酶,具有调节细胞发育、生长、存活和凋亡,调节细胞与ECM(细胞外基质)黏附的功能。
- The factors which destroy this complex will breakdown the homotypic cell adhesion. 任何破坏细胞内该复合体的因素也将使细胞黏附功能丧失。
- Focal adhesion kinase (FAK) is a critical mediator that connects integrin and the downstream signal molecules in integrin-signal transduction pathway, and is the convergence of many signal pathways. 黏着斑激酶(focal adhesion kinase,FAK)是整合素信号转导通路中连接整合素与下游信号分子的媒介,处于细胞内多条信号转导通路的交汇点,能激活多条信号转导通路。
- In the early stage of cell adhesion, as the contractility of actin cytoskeleton reduced, Rho would be activated.2. 细胞形态和微丝骨架(应力纤维)排布的调整;细胞的增殖与迁移等。