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- Tumor suppressor protein p53 肿瘤抑制蛋白质p53
- The SET complex also contains the tumor suppressor protein pp32 and the granzyme A-activated DNase NM23-H1, which is inhibited by SET. SET复合体还含有一种抑癌蛋白pp32和一种具有脱氧核糖核酸酶(DNase)活性的NM23-H1。
- Endogenous angiogenesis inhibitors act as tumor suppressor proteins. 内源性血管生成抑制剂可作为一种抑癌蛋白。
- Cadherins ;Carrier Proteins ;Tumor Suppressor Proteins ; 钙粘着糖蛋白类 ;
- In 2005, researchers at Sloan-Kettering reported that the gene could stop massie tumor growth in prostate cancer een when another tumor suppressor, known as P53, was turned off. 早在2005年，斯隆-凯特琳中心的研究人员就曾报道了在另一种叫做P53的肿瘤抑制基因关闭时，该基因甚至仍然可以阻止前列腺癌大肿瘤生长。
- A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans. pdf本站所有图书及资料均可在子午学术论坛得到应助下载。
- tumor suppressor protein 肿瘤抑制蛋白; 抑癌蛋白
- The human vaccinia virus B1R kinase related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein. 人类牛痘病毒B1R激酶相关激酶VRK1可使肿瘤抑制蛋白p53的Ser18磷酸化，该位点正是mdm-2的结合位点。
- Although inactivation of some tumor suppressor genes such as p53 and p16INK4A has been identified, no known oncogene is commonly activated in hepatocellular carcinomas. 肝癌是亚洲及非洲最常见的恶性肿瘤，其原因可能是由于这些地区肝炎病毒的流行以及经常接触肝癌的特异性致癌物质。
- Keywords Phosphoric monoester hydrolases;Tumor suppressor proteins;Adenoviridae;Endometrial neoplasms;Apoptosis; 磷酸单酯水解酶类;肿瘤抑制蛋白质类;腺病毒科;子宫内膜肿瘤;细胞凋亡;
- The NF1 tumor suppressor encodes a protein product neurofibromin,which functions as a negative regulator of RAS. NF1为肿瘤抑制基因,是RAS的负向调节器。
- Objective To assess the role of the p53 tumor suppressor gene(wild type p53) in G 1 arrest and apoptosis after irradiation in human gastric carcinoma 823 cell lines(BGC823). Methods Three human gastric carcinoma 823 cell lines with different p53 status,i. 目的 评价抑癌基因p53（ 野生型p53） 对照射后人胃癌细胞系（BGC?823） 的G1 期阻滞和凋亡的控制作用。
- A study of tumor suppressor genes on chromosome 9 in glioblastomas. 胶质母细胞瘤9号染色体肿瘤抑制基因的研究。
- Methods Hep3B cells which lack the expression of both p53 and retinoblastoma tumor suppressor genes because of deletions, were transfected with a wild-type (wt) p53 cDNA and control vector by a liposome method. 方法通过采用脂质体介导转染技术，将野生型p53 cDNA导入一种p53和Rb基因缺失的肝癌细胞株Hep3B。
- BRCA1 inactivates a tumor suppressor gene known as PTEN. BRCA1能够使人体内一种叫PTEN的肿瘤抑制基因失去活性。
- The latest progress in molecular mechanisms for transcriptional regulation of 9oncogenes (c-myc, c-fos, c-jun, ETS-2, c-myb, c-erbB_2/neu, c-Ha-ras, c-Ki-ras, c-rel) and2 tumor suppressor genes (Rb, p53) was reviewed. 概述了9种癌基因(c-myc、c-fos、c-jun、ETS-2、c-myb、c-erbB_2/neu、c-Ha-ras、c-Ki-ras、c-rel)和2种抑癌基因(Rb、p53)转录调控的分子机制研究在近年来所取得的主要进展。
- Previous studies have shown the association between colorectal carcinogenesis and the mutation of K-ras and c-myc oncogenes, inactivation of tumor suppressor genes such as P53, APC, DCC, MCC, P53 etc. 研究表明大肠癌的发生与K-ras癌基因突变和P53、APC和DCC等抑癌基因失活有关。
- Background The abrogation of function of the tumor-suppressor protein p53 as a result of mutation of its gene, TP53, is one of the most common genetic alterations in cancer cells. 背景肿瘤抑制蛋白p53由于其基因TP53突变而造成功能缺失，是肿瘤细胞最常见的基因变异。
- Objective:To investigate the expression of multiple tumor suppressor gene (MTS1/P16) protein in the carinogenesis and developmant of esophageal Squamous carcinoma(ESC). 目的探讨多肿瘤抑制基因P16/MTS1在食管鳞状细胞癌形成中的作用。
