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- In-cell Western was used to detect the level,of phospho-ERK1/2 of trophoblast cells treated with CsA. In-cell West- ern检测CsA作用后滋养细胞ERK1/2磷酸化水平。
- AIM: To explore the effect of insulin on apoptosis of cultured human trophoblast cells and its possible mechanism. 目的:探讨胰岛素对培养的滋养细胞凋亡的影响及可能的机制。
- Objective To prepare highly purified human trophoblast cells from human placentae at the first trimester of normal pregnancy. 目的建立人早孕绒毛滋养层细胞有效的分离、培养方法。
- Objective To investigate the expression of human leucocyte antigen protein G (HLA-G) in different trophoblast cells and different stages of pregnancy. 摘要目的探讨人类白细胞抗原G(HLA-G)蛋白在妊娠不同阶段和不同种类滋养细胞的表达差异及生物学意义。
- The aim of this study was to explore whether cyclosporine A(CsA)can modulate expression of MMP-9 and MMP-2 and invasion of the first-trimester human trophoblast cells. 本研究的目的是探讨环孢素A对人早孕期滋养细胞侵袭能力及基质金属蛋白酶9与2 (matrix metalloproteinase 9 and 2,简称MMP-9与MMP-2)表达的调节作用,为治疗反复自然流产等妊娠疾患提供新的线索。
- At last, by treating the cultured human trophoblast cells with CR11 and its inhibitor we study the effects of CR11 on estradiol release by trophoblast cells. 第三部分对离体培养的胎盘滋养叶细胞用CRH及其拮抗剂处理,观察CRH对滋养叶细胞雌二醇合成和释放的影响。
- The direction of blood flow is from the spiral arteries to the microvessels, which suggests that the migration of trophoblast cells is against the stream of blood flow. 在此过程中,子宫脉管中滋养层细胞迁移的方向与血流方向相反,是一种特殊的逆血流而上的迁移。
- Conclusion:5-HTR and SPR can be produced by trophoblast cell of human placenta,which will provide morphological evidence for 5-HT and SP taking part in the regulation... 结论:人胎盘滋养层细胞自身含有5HTR和SPR,为在离体培养条件下研究5HT和SP对胎盘激素的合成与分泌的调控作用提供了形态学依据。
- These results above indicate that CsA can induce the expression of MMP-9 and MMP-2 through activating MAPK/ERK1/2, which contributes to the improved invasion of the first-trimester human trophoblast cells. 结果表明,CsA可激活ERK1/2,通过MAPK/ERK1/2途径促进滋养细胞MMP-9与MMP-2基因的转录与蛋白分泌,从而增强滋养细胞的侵袭能力,对滋养细胞生物学功能具有良性调节作用。
- Metho ds:The EGFR expression in human trophoblast cells of different pregnancy phases was localized by immunohistochemical methods(ABC),and the related quantity of EGFR mRNA was analyzed by RT-PCR method. 方法:采用免疫组织化学方法测定不同孕期滋养层细胞EGFR的表达,应用逆转录-聚合酶链反应(RT-PCR)技术对EGFRmRNA进行分析。
- Therefore,it is inferred that it maybe play a key role in development of preeclampsia.Further deep study on signal transduction of trophoblast cells could help to entirely reveal p... 对滋养细胞信号转导的深入研究,有助于整体上揭示子痫前期的发病机制,随着蛋白激酶用于药物开发的研究,也为子痫前期的治疗提供了新的治疗方向。
- Results HB-EGF can be detected in all villi and decidua of the early pregnant tissue, HB-EGF located on cell membrane and cytoplasm in trophoblast cells and glandular and stromal cells in decidua. 方法采用免疫组化法检测18例早孕绒毛及蜕膜组织中的HB-EGF的表达及定位。
- Conclusion: The expression of HLA-G protein may relate to the invasiveness of trophoblast and malignant changes of trophoblastic cells. 结论:HLA-G蛋白的表达可能与滋养细胞的侵袭行为有关,在滋养细胞肿瘤的侵袭中有一定作用。
- Keywords activin A;follistatin;trophoblast cell; 激活素A;卵泡休止素;滋养层细胞;
- Chorionic-type intermediate trophoblast cell 绒毛膜型中间滋养细胞
- Villi are not present.Rather, there is a proliferation of bizarre trophoblastic cells. 绒毛不存在,明显异型性的胚胎滋养层细胞增殖显著。
- Conclusion LN and LN-R might play an important role in the invasion of trophoblastic cells. 结论在滋养细胞侵袭的过程中,LN和LN-R起着重要作用。
- Objective To explore the relationship between laminin (LN), laminin receptor (LN-R) and the invasion of trophoblastic cells. 摘要目的探讨层黏连蛋白(LN)及层黏连蛋白受体(LN-R)与滋养细胞侵袭的关系。
- Conclusion:Trophoblastic cells in the placental tissue may be the main production source of GM-CSF and G-CSF in human cord blood. 结论:胎盘滋养层细胞可能是产生脐血中GM-CSF和G-CSF的主要细胞。