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- Orphan nuclear receptor steroidogenic factor-1 SF-1
- Orphan nuclear receptor liver receptor homolog-1 and estrogen production 孤儿核受体肝受体同系物-1以及与雌激素相互调节作用
- Keywords Orphan nuclear receptor gene;Adeno-associated virus;BMSCs-NSCs;Parkinson s disease; 孤儿核受体基因;腺相关病毒;骨髓源性神经干细胞;帕金森病;
- Orphan nuclear receptors 孤儿核受体
- Orphan nuclear receptor gene 孤儿核受体基岗
- orphan nuclear receptor 孤儿核受体
- Abstract:The peroxisome proliferator activated receptor (PPAR) belongs to a large family of nuclear receptors. PPAR基因是近年发现的与脂类代谢有重要关联的核受体基因。
- Hepatology Digest: The nuclear receptors are important in cholestatic liver disease. 国际肝病: 核受体在胆汁淤积性肝病很重要。
- Probably the new nuclear receptor ligands such as FXR ligand will be the next compound. 新的核受体配体很可能成为下一代化合物,如FXR配体。
- Their regulation is implemented through interaction between two types of nuclear receptors: retinoic acid receptor(RAR)and retinoid X receptor(RXR). 其调节作用是通过两种核受体的相互作用实现的:视黄酸受体和类视黄醇X受体。
- Nuclear receptors can act alone or interact on each other, and they can also crosstalk with other transcriptional factors. 核受体可单独或相互联系而发挥作用,亦可与其他转录因子进行交互通话。
- One important direction would be to mimic the action of bile acid without having the toxicity of hydrophobic bile acid from the nuclear receptors. 一个重要的途径是通过核受体模拟胆酸的作用,但具有疏水性胆酸的毒性。
- Studies on nuclear receptors related to bile acid metabolism are important to know the regulation mechanism of bile acid metabolism and direct clinical drug usage. 核受体调节胆汁酸代谢的研究近年来已成为国内外研究的热点,研究胆汁酸代谢相关的核受体,对于了解胆汁酸代谢的调节机制,指导胆汁酸代谢相关疾病的临床合理用药以及探索新药等方面有重要意义。
- Objective To determine the ETO interaction domain of nuclear receptor co repressor (N CoR) for abolishing the biological function of AML1 ETO. 目的 为消除急性髓系白血病标志基因AML1/ETO的活性 ,确定核受体辅助抑制因子(nuclearreceptorco repressor,N CoR)与ETO基因相互作用的活性部位。
- Androgen receptor belongs to the nuclear receptor superfamily and is a ligand-dependent transcription regulator, which can be activated by androgen. 雄激素受体属于核受体超家族,为配体依赖性基因转录因子,与雄激素结合后被激活。
- Trauner: One important direction is that these nuclear receptors target transport systems and enzymes involved in bile formation and bile detoxification. 例如,利福平或者苯巴比妥、甚至一些用于治疗新生儿黄疸的传统中草药,这些已知所具有的酶诱导效应实际上是因核受体诱导位点所致。
- The androgen receptor(AR)belongs to the steroid receptor family,which is a part of the large nuclear receptor superfamily. 雄激素受体(AR)属于核受体超家族中的类固醇受体。
- The Nuclear Receptor Coactivator AIB1 Mediates Insulin-like Growth Factor I-induced Phenotypic Changes in Human Breast Cancer Cells. 主要学术内容和意义:核受体辅激活子AIB1(乳腺癌中扩增)在人类乳腺癌细胞中通过雌激素信号过表达。
- This article reviewed the advance in study on nuclear receptor mediating cell proliferation differentiation and apoptosis. 现就核受体介导细胞增殖、分化与凋亡的作用机制研究进展做一综述。
- The discovery that the HR protein is a nuclear receptor corepressor indicated that HR function in hair cycling is by regulating gene expression. HR蛋白是细胞核受体辅阻遏物的发现证明HR蛋白是通过在毛发周期中调节基因表达来发挥作用的。
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