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- Objective To determine the ETO interaction domain of nuclear receptor co repressor (N CoR) for abolishing the biological function of AML1 ETO. 目的 为消除急性髓系白血病标志基因AML1/ETO的活性 ,确定核受体辅助抑制因子(nuclearreceptorco repressor,N CoR)与ETO基因相互作用的活性部位。
- Keywords Leukemia;myeloid;Nuclear receptor co repressor;Gene;ETO; 关键词白血病;髓系;核受体辅助抑制因子;基因;ETO;
- Probably the new nuclear receptor ligands such as FXR ligand will be the next compound. 新的核受体配体很可能成为下一代化合物，如FXR配体。
- Androgen receptor belongs to the nuclear receptor superfamily and is a ligand-dependent transcription regulator, which can be activated by androgen. 雄激素受体属于核受体超家族，为配体依赖性基因转录因子，与雄激素结合后被激活。
- The androgen receptor(AR)belongs to the steroid receptor family,which is a part of the large nuclear receptor superfamily. 雄激素受体(AR)属于核受体超家族中的类固醇受体。
- The Nuclear Receptor Coactivator AIB1 Mediates Insulin-like Growth Factor I-induced Phenotypic Changes in Human Breast Cancer Cells. 主要学术内容和意义：核受体辅激活子AIB1（乳腺癌中扩增）在人类乳腺癌细胞中通过雌激素信号过表达。
- This article reviewed the advance in study on nuclear receptor mediating cell proliferation differentiation and apoptosis. 现就核受体介导细胞增殖、分化与凋亡的作用机制研究进展做一综述。
- The discovery that the HR protein is a nuclear receptor corepressor indicated that HR function in hair cycling is by regulating gene expression. HR蛋白是细胞核受体辅阻遏物的发现证明HR蛋白是通过在毛发周期中调节基因表达来发挥作用的。
- In this article, we reviewed the research advancement in the signal transduction pathway of nuclear receptor and membrane receptor during the activation of hepatic stellate cells. 本文就肝星状细胞激活过程中一些重要的膜受体、核受体信号转导途径及其研究进展作一综述。
- Recent work linking these pathways in epithelial stem cell differentiation has come from studies analyzing the in vivo function of the nuclear receptor corepressor, Hairless (HR). 近来的有关表皮干细胞分化的途径的工作基于分析细胞核受体辅阻遏物HR的体内作用的研究。
- Abstract ：Nuclear receptor (NR) is a ligand-dependent transcriptional factor which plays an important role in the metabolism of xenobiotics and endobiotics. 摘 要 ：核受体是一种配体依赖性转录因子，在外源性物质和内源性物质的代谢中具有重要作用。
- Until now, many nuclear receptor coactivators were cloned including RIP 140, CBP/P300, SRC/pl60, CARM-1, TRAP/DRIP, and the newly discovered SRA (a small RNA molecular serving as a coactivator). 迄今已分离鉴定出大量的核受体辅活化子，如RIP140、CBP/P300、SRC/p160家族、CARM-1、TRAP/DRIP等，包括最近发现的SRA(一种有辅活化子功能的RNA)。
- Estrogen receptor (ER), an important transcription factor belonging to the nuclear receptor superfamily, plays a key role in reproductive, cardiovascular and central nervous systems and bone tissue. 摘要雌激素受体属于核受体超家族成员，是一类重要的核转录因子，它在生殖系统、骨组织、心血管和中枢神经系统中发挥著重要的生理作用，是治疗骨质疏松和乳腺癌的重要药物作用靶标。
- Objective To investigate the localization and expression pattern of nuclear receptor NR4A1 protein in follicle and corpus luteum cells at different estrous stages in cycling female SD rat. 目的：通过研究核受体NR4A1蛋白在正常雌性SD大鼠不同卵巢功能周期的不同发育阶段卵泡及黄体细胞中的表达，推测其在卵泡发育中的生物学作用。
- Estrogen receptor(ER),an important transcription factor belonging to the nuclear receptor superfamily,plays a key role in reproductive,cardiovascular and central nervous systems and bone tissue. 雌激素受体属于核受体超家族成员,是一类重要的核转录因子,它在生殖系统、骨组织、心血管和中枢神经系统中发挥着重要的生理作用,是治疗骨质疏松和乳腺癌的重要药物作用靶标。
- The reason is inferred in the introduction of Y to replace the volume of heterocyclic DepartmentMuch of the substituent on the XXX and YYY mother nuclear receptor steric combination. 推断其原因是在Y取代杂环处引入体积太大的取代基会对XXX的YYY母核与受体的结合产生空间位阻。
- Abstract:The peroxisome proliferator activated receptor (PPAR) belongs to a large family of nuclear receptors. PPAR基因是近年发现的与脂类代谢有重要关联的核受体基因。
- Hepatology Digest: The nuclear receptors are important in cholestatic liver disease. 国际肝病: 核受体在胆汁淤积性肝病很重要。
- Their regulation is implemented through interaction between two types of nuclear receptors: retinoic acid receptor（RAR)and retinoid X receptor（RXR）. 其调节作用是通过两种核受体的相互作用实现的：视黄酸受体和类视黄醇X受体。
- Chiyoda Mutual Life Insurance Co. 千代田寿险公司(日本)
