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- Studies on the Protection and Immune Mechanism of Oral Islet-cell Associated Antigens in NOD Mice. 口服胰岛细胞相关抗原预防NOD小鼠糖尿病发生及其免疫机制的实验研究
- Result: Expression of Fas protein at 15th week was stronger than 4th week in NOD mice. 巧周龄时胰岛细胞FaS蛋白表达与4周龄时相比显著增强,FaSL蛋白表达无显著性差异。
- To find out the role of Aire in self tolerance and autoimmunity, we constructed Aire transgenic NOD mice. 结果通过对Aire转基因NOD鼠的生物学性状分析,我们发现:转基因鼠的胸腺明显小于非转基因鼠。 这种现象不受年龄,性别的影响。
- Results Administering GAD65 protein to female NOD mice could significantly suppress their diabetes and insulitis. 结果重组GAD65蛋白能明显降低NOD小鼠糖尿病的发生和胰岛炎的严重程度。
- Prevention of insulitis by glutamic acid decarboxylase in NOD mice Yang Zhulin,Zhou Zhiguang,Wu Hanwen,et al. 中华内分泌代谢杂志1998年第5期第14卷论著作者:杨竹林周智广伍汉文廖二元杨文单位:410011湖南医科大学代谢内分泌研究所...
- Objective:To investigate the effects of AIRE on T1DM development by detecting the expression of AIRE in NOD mice and PBMC of T1DM patients. 目的:通过检测AIRE(AutoImmueREgulator)基因在NOD(Nonobesediabetic)鼠相关组织及1型糖尿病(Type1diabetesmellitus,T1DM)病人PBMC中的表达,从分子水平上探讨AIRE在免疫耐受中的作用。
- This result indicated that Aire might involve in the development ofthymus of NOD mice and therefore influence the T cells education. 这提示了Aire有可能参与NOD鼠胸腺发育并进而影响T细胞发育。 通过对胸腺组织细胞进行FACS及组织切片染色分析,我们发现,与非转基因鼠相比,在转基因鼠胸腺,尤其是髓质部份,存在更多的凋亡细胞。
- The mechanism of oral administration of insulin inducing immune tolerance in NOD mice[J].Chin J Endocrinol Metab,2002,18(1):67-68. NOD小鼠口服胰岛素诱导免疫耐受机制探讨[J].;中华内分泌代谢杂志;2002;18(1):67-68
- Methods Female NOD mice,6 weeks old,were administered with GAD65 protein three times a week via gavage for 6 to 56 weeks. 方法6周龄NOD雌鼠1周3次灌胃重组GAD65蛋白,共32周,观测胰岛炎和糖尿病发病。
- Objective To further investigate the molecular mechanism underlying the preventive effect of Astragalus polysaccharide (APS) on type 1 diabetes mellitus (DM) in NOD mice. 目的 深入探讨黄芪多糖 (APS)对NOD小鼠 1型糖尿病预防作用的分子机制。
- She greeted us with a nod of the head. 她向我们点点头打招呼。
- It is natural for a cat to catch mice. 猫捉老鼠是本能。
- The Role of Aire in the Development of Diabetes in NOD Mice 自身免疫调节因子(AIRE)在NOD鼠糖尿病发病中的作用研究
- I often nod off for a little while after lunch. 我在午饭後常睡一小觉。
- She passed by with only a distant nod. 她只冷淡地点了一下头就走了过去。
- The mice have chewed away some of the woodwork. 老鼠已经啃坏了一些木制品。
- He left without so much as a nod. 他连头也不点一下就离开了。
- He gave an almost imperceptible nod. 他略一点头,别人几乎无法察觉。
- The mice have eaten away some of the wood-work. 老鼠把一些木制品给啃坏了。
- The mice have nibbled a hole in the cheese. 老鼠在奶酪上啃出了一个洞。