Objective:To investigate the effects of AIRE on T1DM development by detecting the expression of AIRE in NOD mice and PBMC of T1DM patients.

• 目的:通过检测AIRE(AutoImmueREgulator)基因在NOD(Nonobesediabetic)鼠相关组织及1型糖尿病(Type1diabetesmellitus,T1DM)病人PBMC中的表达,从分子水平上探讨AIRE在免疫耐受中的作用。