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- MUC1 VNTR 黏蛋白l串联重复区
- The gene mutation of IL-1 a C-889T IL-lRaT+8006C and IL-IRa VNTR may influence the serum IL-1 a and IL-IRa levels. IL一laC一889T、IL一IRaT+8006C和IL一IRa VNTR基因突变可影响血清IL一la和IL一IRa的水平。
- Methods The VNTR polymorphism in intron 4of the eNos genes of PAH COPD and healthy control were detected by PCR. 方法应用PCR检测COPD肺动脉高压患者和健康对照组的eNos基因第4内含子多态性。
- MUC1 is a high molecular weight glycoprotein, which is over-expressed on the epithelium originated tumor. 摘要MUC1是一类高相对分子质量的糖蛋白，在上皮来源的肿瘤组织中高表达。
- Objective To screen two MUC1 antigen mimic epitopes by phage display peptide library technology. 目的从噬菌体表面展示的随机12肽库中筛选出MUC1抗原的模拟表位。
- Genotype distribution of milk MUC1 in Boer goat,Chengdu Ma goat and Jianchang black goat is in accordance with Hardy-Weinberg law. 而在成都麻羊中仅发现CC基因型。 经适合性检验 ,波尔山羊、成都麻羊、建昌黑山羊乳MUC1基因座基因型分布符合哈代 -温伯格定律
- Methods: SP immunohistochemistry technique was used to evaluate the expression of mucin MUC1 in 90 cases of serous and mucinous ovarian tumors. 方法：免疫组化S-P法检测90例卵巢浆液性和黏液性肿瘤的黏蛋白MUC1的表达。
- Objective: To study mucin MUC1 expression and clinical pathological features relationship in serous and mucinous ovarian tumors. 摘要目的：探讨卵巢浆液性和黏液性肿瘤中黏蛋白MUC1的表达与临床病理特征的相关性。
- AIM To construct an eukaryotic expression vector containing the coding region of human full length MUC1 gene and to detect its expression in COS 7 cells. 目的 构建含人 MUC- 1全长 c DNA序列的真核表达载体 ;并观察其在 COS- 7细胞中的表达 .
- The expression of Muc1 is closely associated with the growth and transformation of breast cancer,which can be considered as estimation of breast cancer prognosis. Muc1表达与乳腺癌的转移具有密切关系,对于乳腺癌的预后判断有一定意义。
- MUC1, a transmembrane glycoprotein, is less expressedin many normal epithelial cells and overexpresses in cancercells such as breast cancer, ovarian cancer and so on. 本研究发现MUC1在乳癌、乳腺良性肿瘤和癌旁正常乳腺组织中均有不同强度和部位的表达。
- This review reevaluates the function of the MUC1 on the tumorigenesis and development of the tumor and the application on the tumor diagnosis and immunotherapy. 本文主要阐述MUC1在肿瘤发生发展及其在肿瘤诊断和生物治疗中的作用。
- Objective To study the variable number tandem repeats(VNTR)polymorphism in intron 4 of the endothelial nitric oxide synthase(eNos)gene and its relationship with plasma NO in patents with PAH of COPD. 目的探讨内皮型一氧化氮合酶(endothelial nitricoxide syehtase,eNos)基因第4内含子27bp可变数目的短片段重复序列(variable number tandem repeats,VNTR)的多态性现象与慢性阻塞性肺部疾病(COPD)肺动脉高压的相关性。
- MUC1 is the only mucin that is an integral membrane protein composed of core peptide and carbohytrate side chain expressing on normal epithelia cells and carcinoma cells. MUC1是mucin粘蛋白家族成员，存在于正常腺管上皮细胞及其来源的肿瘤细胞表面，由多肽核心和侧枝糖链构成。
- ObjectiveTo investigate the relationship between 48bp variant number tandem repeat (VNTR) polymorphism in the third exon of dopamine D 4 receptor(DRD 4) gene and attention deficit hyperactivity disorder (ADHD). 目的 探讨多巴胺D4受体 (dopamineD4receptor,DRD4 )基因 48bp可变重复序列 (variantnumbertandemrepeat,VNTR)多态性与注意缺陷多动障碍(Attention deficithyperactivitydisorder,ADHD)及其相关症状的关系。
- Materials and methods: Polymorphic analysis of MCC, DCC and YNZ22 loci that contain a variable number of tandem repeat(VNTR) was performed in 41 surgical specimens of colorectal carcinoma by the polymerase chain reaction(PCR). 方法：应用多聚酶链反应技术对41例大肠癌MCC、DCC基因和YNZ22位点的数量可变的重复序列（VNTR）区进行了分析。
- Restriction analysis and DNA sequencing showed that the recombinant plasmid contained the coding region of human full length MUC1 gene. Transfection experiment verified that MUC1 gene could be expressed in COS 7 cells. 酶切鉴定和序列分析证实 ;重组质粒含有人MU C- 1全长 c DNA编码序列 ;转染实验表明 MU C- 1基因能在 COS- 7细胞中表达 .
- METHO DS: The expression of MUC1 and MDR1 genes were measured in 34 patients with non- M3 subtype acute leukemia by reverse transcription-polymerase chain reaction (RT -PCR); their correlations to clinical treatment efficacy were observed. 方法:应用逆转录鄄聚合酶链反应(RT鄄PCR)法检测34例初治非M3型急性白血病患者MUC1和MDR1的表达,并观察两种基因表达及其与临床疗效的关系。
- This study was desig ned to investig ate the relationship betwe en the expression of MUC1,CD44v6,nm23in g astric carcinomas and reg ional lym ph node tissues and invasion,metast asis ,and prog nosis of the tumor. 本实验旨在探讨胃癌组织及区域淋巴结中MUC1、CD44v6、nm23表达与胃癌侵袭转移及预后的关系。
- MUC1 was related with WHO pathological grades, FIGO clinical stage, the greater omental metastasis.Mucin MUC1 is an excellent indicator for benign and malignant tumor in ovarian epithelial tumor. 结论：粘蛋白MUC1的在恶性卵巢上皮性肿瘤中呈高表达，其表达强度与WHO病理分级、FIGO临床分期、大网转移相关，因此，MUC1的表达可作为卵巢上皮性肿瘤的良、恶性的检测指标。
