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- Janus激酶抑制剂／AG490janus kinase inhibitor/AG490
- AG490(JAK2激酶抑制剂)组(n=24)：CLP前20mins皮下注射AG490 8.0 mg/kg，然后于CLP后2、6、24和48h活杀；AG490 treatment group (n=24): subcutaneous injection of AG490 at a dose of 8.0mg/kg at 20mins prior to CLP, being further divided respectively into 2h, 6h, 24h and 48h post-CLP subgroups;
- 目的:探讨Janus激酶(Janus kinase,JAK)特异性抑制剂AG490阻断STAT3信号转导通路对高表达STAT3的人胰腺癌细胞系SW1990生长增殖的作用及其机制。Objective:To investigate the effect of blocking signal transducer and activator of transcription 3(STAT3) signaling pathway by Janus kinase(JAK) specific inhibitor AG490 on the growth and proliferation of SW1990 human pancreatic cancer cell line harboring constitutive active STAT3 and the underlying mechanism.
- Janus激酶2Janus kinase 2
- 低氧刺激复合培养的平滑肌细胞表达Janus激酶Expression of Janus kinase in co-cultured pulmonary arterial smooth muscle cells by hypoxia
- 酪氨酸蛋白激酶抑制剂对正常人角质形成细胞增殖的影响Effect of tyrosine kinase inhibitor on proliferation of human keratinocytes cultured in vitro
- 脂多糖对复合培养的微血管内皮细胞Janus激酶表达的影响Effect of lipopolysaccharide on Janus kinase expressions in cocultured lung microvascular endothelial cells
- 低氧时复合培养的肺动脉平滑肌细胞Janus激酶蛋白表达的状况Expression of Janus kinase protein in cocultured PASMC in hypoxia
- 酪氨酸激酶抑制剂对气道上皮细胞上皮钙粘附素表达的影响Effect of Tyrosine Kinase Inhibitor on E-cadherin Expression in Airway Epithelial Cells
- 安全膨胀抑制剂safe expansive inhibitor
- 结论 LPS可诱导大鼠腹腔巨噬细胞HMGB1mRNA表达 ,其诱生机制与Janus激酶 /信号转导子和转录激活因子 (JAK/STAT )途径密切相关。Janus kinase/STAT pathway may be involved in modulating HMGB1 mRNA expression in LPS-activated macrophages.
- 变构抑制剂allosteric inhibitor
- 不可逆抑制剂irreversible inhibitor
- 产卵抑制剂oviposition inhibitor
- 泡沫抑制剂foam suppressor
- 前期抑制剂prophase inhibitor
- 脲酶抑制剂urease inhibitor
- 取食抑制剂feeding deterrent
- 细菌抑制剂bacterial inhibitor
- 乳化抑制剂emulsion inhibitor
