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- LOH of DCC gene may be involved in the occurrence and development of HCC. DCC基因LOH可能参与了原发肝癌的发生发展。
- Correlation Between the Mutation of the DCC Gene Codon 201 and Gastric Cancer. DCC基因201密码子突变与胃癌相关性的研究
- No significant correlation was found among LOH of DCC gene, clinical parameters and HBV infection. DCC基因LOH与临床病理参数和HBV感染无显著相关。
- Objective:To understand DCC gene status between primary and liver metastatic lesions of large intestinal cancer. 目的:了解DCC基因在大肠癌复发、转移过程中的变化及其与肝转移的关系.
- DCC gene play an important role in controlling cancer recurrence after operation. DCC基因可能是决定大肠癌术后复发重要的控制基因之一;检测DCC表达有助于判断大肠癌的预后.
- DCC gene played an important role in generation and development of ovarian carcinomas. DCC基因可明显抑制卵巢癌细胞生长,可能在卵巢癌发生、发展的过程中起重要作用。
- The expression of DCC gene was decreased the cancer, which was related to the recurrence. 大肠癌DCC基因蛋白多数呈阴性表达;且与局部复发关系密切;局部复发者DCC表达下降明显.
- Results:The expression of DCC gene was decreased the cancer, which was related to the recurrence. 结果:大肠癌DCC基因蛋白多数呈阴性表达;且与局部复发关系密切;局部复发者DCC表达下降明显.
- Objective: To study the relationship between DCC gene expression and recurrence and reoperation of large intestinal cancer after radical operation. 目的:探讨DCC基因在大肠癌复发中的临床意义及其与再手术预后的关系.
- The results indicated that loss of DCC gene expression may play an important role in ovarian carcinomas and its progression. DCC基因表达缺失与卵巢恶性肿瘤的发生、发展及转移、浸润有关。
- METHODS Polymorphisms of DCC gene STR was studied by PCR STR in 52 unrelated individuals and 57 atherosclerosis samples in Shaanxi people. 方法 利用 PCR- STR方法对陕西正常老年人群 (5 2例 )动脉粥样硬化 (5 7例 )的 DCC基因STR位点多态性进行群体遗传学研究 ;并就该位点与动脉粥样硬化关系进行关联分析 .
- Main reagent : dilution fluid, hemolysis fluid, Bcr/Abl(P230) , primer and probe of GAPDH gene, primer of DCC gene, RNA extracting fluid, cDNA kit. 主要试剂：血液稀释液、溶血液、Bcr/Abl(P230)和内参GAPDH基因引物及探针、DCC基因引物、RNA提取液、cDNA合成试剂盒，乙酸钠-柠檬酸缓冲液(pH：4.;3)为流动相。
- DCC gene is an important tumor suppressor gene, and its alterations play a role in thepathogenesis and progression of colorectal cancer. DCC基因是一个在结直肠肿瘤发生发展中起重要作用的抑癌基因，该基因的异常与结直肠癌发生发展有关。
- Objective: To explore the role of the loss of heterozygosity (LOH) of DCC gene in the occurrence and development of primary hepatocellular cancer (HCC). 目的：了解结肠癌缺失基因（DCC基因）在原发肝癌发生发展中的作用。
- This article is to evaluate the role of DCC gene alteration in the development and progression of gastric cancer, as well as to correlate with its prognosis. 为了解DCC基因改变在胃癌发生发展中的作用及与临床预后的关系,本文对45例手术切除胃癌组织DCC基因杂合性缺失进行分析。
- AIM To study the relationship between genetic polymorphisms of DCC gene STR in Shaanxi people and its possible association with the susceptibility of atherosclerosis. 目的 探讨 DCC基因 STR位点多态性与动脉粥样硬化遗传易感性之间的关系 .
- The inactivation of DCC gene is an important factor which influences prognosis of large intestinal cancer. The mechanism of DCC gene inactivation is mainly DCC sequence mutation. 结论:DCC基因失活可能是影响大肠癌预后的重要因素之一;肝转移者发生DCC表达失活的主要机制是发生了基因突变.
- The machinism that DCC gene influences the colorectal carcinoma expressing type may be the loss of its ability in inhibitting cell proliferation when it is inactived. 其可能作用机制是DCC基因失活后导致其抑制细胞增殖的特性丧失，从而使大肠癌细胞获得更强的浸润和转移能力。
- The DCC gene encodes a protein belonging to the immunoglobulin superfamily with similarity to the N-CAM transmembrane proteins, and it is a putative tumor-suppressor gene. DCC基因负责制造一个属于超科免疫球蛋白之蛋白，此蛋白与N-CAM穿膜蛋白相似，DCC基因是一个推想中之抑癌基因；
- Conclusions The reduced expression of DCC gene was regarded as an independent factor that identified metastasis potential and prognosis of colorectal cancer. 结论 DCC基因的表达缺失可以作为判断大肠癌转移潜能及预后的独立指标。
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