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- Cell cycle is mainly regulated by cyclin, cyclin dependent kinase(CDK) and cyclin dependentkinase inhibitor (CDKI). 细胞周期主要是由细胞周期蛋白(cyclin)，细胞周期蛋白依赖性激酶(CDKs)和CDK抑制蛋白(CDKI)来调控的。
- Protein serine theronine phosphatase inhibitor or cyclin dependent kinase( CDK) inhibitors could abolish the enhancement. 而蛋白丝氨酸苏氨酸磷酸酯酶抑制剂以及细胞周期蛋白依赖性激酶(DK)制剂可阻断该凋亡敏感性增强效应。
- In the recent years, cyclin, cyc-lin dependent kinase and cyclin dependent kinase inhibitor have important effect in cell cycle modulation. 近年来发现细胞周期素(Cyclin)、细胞周期蛋白依赖激酶(Cyclin dependent kinase，CDK)和细胞周期蛋白依赖性激酶抑制因子(Cyclin dependent kinase inhibitor，CKI)在真核生物细胞周期调控有重要作用。
- P21WAF1 is a kind of cyclin dependent kinase inhibitor, it can be bind to several kinds of cyclin/CDK compounds and arrest the cell cycle. P21~(WAF1)是一种CKI，它可与多种cyclin/CDK复合物结合，引起细胞周期阻滞。
- It is well known that cell cycle in eukaryotic cells is controlled by various complexes composed of cyclin and cyclin dependent kinase (CDK). 真核细胞周期是受细胞周期蛋白(cyclin)和细胞周期蛋白依赖激酶(cyclin dependent kinase,CDK)组成的蛋白复合体调控。
- Objective To investigate roles of cyclin dependent kinase 4 (CDK4) in nordihydroguaiaretic acid (NDGA) induced inhibitory effect on proliferation of human malignant glioma cells. 目的 探讨细胞周期蛋白依赖性蛋白激酶 4(CDK4)在去甲二氢愈创木酸 (NDGA)抑制人恶性胶质瘤细胞系SHG 44细胞增殖中的作用。
- Objective: To study the relationship between cyclin dependent kinase 4 (CDK4),PTEN protein expression and carcinogensis、progression and recurrence of endometrial carcinoma . 目的：探讨PTEN、CDK4蛋白表达与子宫内膜癌的发生、发展及复发的关系。
- Objective To investigate the role of proliferating cell nuclear antigen (PCNA) and cyclin dependent kinase 2 (CDK2) in inhibition of vascular smooth muscle cells (VSMCs) proliferation by gax gene. 目的 研究增殖细胞核抗原 (PCNA)和细胞周期蛋白依赖性激酶 2 (CDK2 )在gax基因抑制血管平滑肌细胞 (VSMC)增殖中的作用。
- ObjectiveTo explore the abnormalities of expression of p16,retinoblastoma(RB),cyclinD1,cyclin dependent kinase 4(CDK4)genes and the relationship between these abnormalities and the cell proliferation in glioblastomas(GBMs). 目的探讨胶质母细胞瘤中p16基因、视网膜母细胞瘤基因 (retinoblastomagene,RB)、细胞周期蛋白D1(cyclinD1)基因、细胞周期蛋白依赖性激酶 4 (cyclindependentkinase 4 ,CDK4 )基因表达的异常及其与细胞增殖活性之间的关系。
- There are many factors that regulate the proliferation and differentiation of cells. The major factors include cyclin, cyclin dependent kinase (cdk) and cyclin dependent kinase inhibitor (CDKI). 调节细胞增殖和分化的因素有许多种，其中主要有细胞周期蛋白(cyclin)、细胞周期蛋白依赖性激酶(cyclin dependent kinase，cdk)和细胞周期蛋白依赖性激酶抑制因子(cyclin dependent kinase inhibitor,CDKI)。
- Purpose To investigate the roles of cyclin dependent kinase (cdk) 2 and cdk4 in the pathogenesis of benign prostatic hyperplasia (BPH) and prostatic carcinoma (PC) and their relation to PCNA. 目的：探讨细胞周期蛋白依赖性激酶cdk2和cdk4在前列腺增生（BPH）和前列腺癌（PC）的发生发展过程中作用及其与PCNA之间关系。
- Objective: To study the expression of cyclin dependant kinase 4(CDK4) protein in oral carcinogenesis. 目的：探讨CDK4蛋白在口腔粘膜癌变过程中表达的变化规律。
- cyclin dependent kinase inhibitor CK1
- cyclin dependent kinase inhibitors CDK抑制蛋白
- Cyclin dependent kinase 4 (CDK4) 细胞周期蛋白依赖性激酶4
- Cell cycle cyclin dependent kinase inhibitors(CKIs) 细胞周期
- Methods Expressions of cyclin E and cyclin dependent kinases 2(cdk2)in 38 cases of lung cancer and 6 cases of normal lung tissues were examined by immunohistochemistry. 方法 :应用免疫组化方法检测细胞周期蛋白E(cyclinE)和细胞周期蛋白依赖性激酶 2 (cdk2 )在 38例肺癌和 6例正常肺组织中的表达状况。
- Objective To study the role of cycline dependent kinase 4(CDK4) in the malignant transformation of human fetal lung diploid fibroblast cell(2BS) induced by silica. 目的 探讨细胞周期蛋白依赖激酶K4(CDK4)在石英致人胚肺成纤维细胞(2BS)恶性转化过程中所起的作用,为石英致癌机制提供理论依据。
- To study the effect of the specific cyclin dependent kinases (CDKs) inhibitor Olomoucine on apoptosis induced by low potassium and its mechanisms by using agarose gel eletrophoresis and SAPK/JNK assay kit rto measure SAPK/JNK activity. 目的 :研究化学合成的蛋白激酶抑制剂Olomoucine对低钾诱导的小脑颗粒神经元凋亡的作用及机制。 方法 :体外神经元培养、凝胶电泳和SAPK/JNK分析盒测定JNK(c -Jun氨基末端激酶 )活性。
- Cyclin dependent kinase inhibitor and its application in ophthalmology 细胞周期依赖性激酶抑制剂及其在眼科的应用
