ObjectiveTo explore the abnormalities of expression of p16,retinoblastoma(RB),cyclinD1,cyclin dependent kinase 4(CDK4)genes and the relationship between these abnormalities and the cell proliferation in glioblastomas(GBMs).

• 目的探讨胶质母细胞瘤中p16基因、视网膜母细胞瘤基因 (retinoblastomagene,RB)、细胞周期蛋白D1(cyclinD1)基因、细胞周期蛋白依赖性激酶 4 (cyclindependentkinase 4 ,CDK4 )基因表达的异常及其与细胞增殖活性之间的关系。