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- The expression of cyclin D1 and CDK4 were detected by RT PCR method. RT PCR检测细胞周期素D1(cyclinD1)、细胞周期蛋白依赖激酶 4 (CDK4 )mR NA的表达。
- Patients who expressed cyclin D1 were more likely to achieve a response. 表达细胞周期蛋白D1的患者更有可能对治疗有反应。
- Objective To clarify the role of a cell cycle regulator, cyclin D1 and CDK6 in patients with gastric carcinoma. 目的检测细胞周期蛋白D1(cyclin D1)和细胞周期蛋白质依赖激酶6(CDK6)在胃癌组织中的表达情况,分析其表达与胃癌的临床病理因素和预后之间的关系。
- Ribozyme targeting cyclin Dl may effectively inhibit cyclin D1 expression and activation in the HSC T6 cell line. 载体表达的特异性核酶能有效地抑制HSC的细胞周期蛋白D1的表达和激活。
- Conclusions: Overexpression of cyclin D1 and CDK4 may involve in the onco-pathogenesis of ESC. 我们在相应的癌旁组织中亦发现cyclin D1和 CDK4的过表达。
- Cyclin D1 and CDK4 proteins were expressed correctly in insect cells and had their biological activity. 成功构建了细胞周期蛋白D1及CDK4真核杆状病毒表达载体 ;并且在昆虫细胞中正确表达了具有生物活性的细胞周期蛋白D1及CDK4融合蛋白 .
- Methods The expression of Cyclin D1, Rb in BDC was detected by immunochemical staining(S P method). 方法 采用S P法进行CyclinD1,Rb的免疫组化染色。
- The increase expression of cyclin D1 and CDK4 possibly related to the differentiation of ESC. 结论:cyclin D1和 CDK4的过表达可能参与食管癌的发生,两者的表达增加与食管癌的分化程度相关;
- Ccylin D1 and Rb are correlated with some clinicopathologic parameter of BDC, and Cyclin D1 is a valuable prognostic marker of BDC. CyclinD1,Rb都与胆管癌的一些临床病理参数有关 ,CyclinD1还是提示胆管癌预后的良好标志物。
- The protein expression of p53 and cyclin D1 increased significantly but the protein expression of p21 decreased significantly(P<0.01). p21WAF/CIP1基因蛋白表达在低剂量染毒30 d组呈阳性表达;高剂量染毒60 d组表达明显下调(P<0.;01)。
- Objective:To investigate the expression and value of P16INK4A, CDK4 and cyclin D1 protein in uterine smooth muscle tumors. 目的:探讨P16INK4A、CDK4和细胞周期蛋白D1(cyclin D1)在子宫平滑肌肿瘤中的表达及意义。
- Reverse Transcription (RT) PCR. The mRNA expressions of cyclin D1, cyclin B1, CDK4, cdc2 and p21 were determined by RT-PCR semi-quantitatively. 逆转录PCR(RT-PCR):应用RT-PCR半定量检测细胞cyclin D1、cyclin B1、CDK4、CDK1、p21的mRNA表达。
- Expression of cyclin D1 could not be detected in Bowen's disease , AK or BCC. On the other hand, high expression of cyclin D1 was found in SCC. 细胞周期素 D1在 Bowen病、基底细胞癌及日光性角化病均无表达,而在鳞状细胞癌表达率很高。
- Futhermore it showed higher expression of CDK4 and lower expression of cyclin D1 and p16 in comparison with cells only treated with t BHP. 进一步发现用Rg1预处理后 ,p16、cyclinD1表达水平降低、CDK4表达水平增加。
- The aberrant expression of Pin1 and Cyclin D1 may play an important role in the pathogenesis and progression of Acute Leukemia. 结论结论Pin1的表达与Cyclin D1的表达密切相关,Pin1和CyclinD1的异常表达可能参与了急性白血病的发生发展。
- The abnormal expression of Cyclin D1 and p16 gene proteins may be one of major pathogeneses of gastric mucosa injury and cell canceration in DGR. Cyclin D1、p16蛋白表达异常是DGR胃黏膜损伤及癌变的分子机制之一。
- Cyclin D1 and CDK4 expression vectors which can express Cyclin D1 and CDK4 fusion proteins are successfully constructed. 本研究成功构建了细胞周期蛋白D1及CDK4原核表达载体,后两者在细胞内能正确表达细胞周期蛋白D1及CDK4融合蛋白。
- Quercetin can act on the G1/S check point of transplantation tumor, inhibits the cell proliferation and cyclin D1 expression of transplantation tumor, retards the growth of tumor. 槲皮素可作用于MCF 7移植瘤的G1/S节点 ,可抑制移植瘤细胞增殖及cyclinD1表达 ,延缓肿瘤生长。
- These results suggest that the down regulation of cyclin D1, CDK4 and pRb proteins may be related to the effects of cholesterol deficiency on proliferation of Jurkat cells. 结果提示,无论是内源性还是外源性胆固醇的缺乏都能抑制Jurkat细胞的增殖,推测这种变化可能与cyclin D1、CDK4及pRb 蛋白表达量的下降而导致相应的cyclin D1/CDK4复合活性下降有关
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- 深远海浮式风电平台 - deep-sea floating wind power platform
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- 京雄高速公路 - Beijing-Xiongan expressway
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- 农业及相关产业增加值 - the added value of agriculture and related industries